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Family Polypodiaceae
Pakpak lawin
Drynaria quercifolia (Linn.) J. Sm.

Li ye hu jue

Common names  Common names 
Drynaria quercifolia (Linn.) J. Sm. Baga-baga (Pamp.) 
Polypodium quercifolium L. Gona-tibatib (Pamp.) 
  Kabkab (Bis., Bik.) 
  Kabkabin (Bis.) 
  Kabkaban (Bis.) 
  Kappa-pappa (Ilk.) 
  Pako (Tag.) 
  Paipai-amo (Tag.) 
  Pakpak lawin (Tag.) 
  Saga (Ig.) 
  Basket fern (Engl.)
  Oak-leaf fern (Engl.)
  Squirrel head (Engl.)
Pakpak-lauin is a local name for three different herbal plant s, two of the genus Asplenium and one of genus Drynaria: Pakpak-lauin: Asplenium nidus; Pakpak-lauin na babae: Asplenium macrophyllum; and Pakpak lawin: Drynaria quercifloia.
Note: There are some dissimilarities in Quisumbing's 1978 publication of Medicinal Plants of the Philippines and the Plants of the Philippines 1964 publication by the University of the Philippines. The former refers to Asplenium nidus as pakpak-lauin and the latter as pasdak; both refer to it as Bird's nest fern. The Plants of the Philippines publication has a Pakpak lawin entree with the scientific designation of Drynaria quercifolia.
Drynaria quercifolia (L.) J. Sm. is an accepted name. The Plant List

Other vernacular names
BANGLADESH: Fo lo rere, Chilo vasa.
BENGALI: Pankhiraj, Pankha, Gurar.
CHINESE: Li ye hu jue.
HINDI: Asvakatri, Katikapan, Basingh
MALAYALAM: Matilpanna, Pannakizhangu, Pannikizangu.
SANSKRIT: Aswakatri.
THAI: Huawaw.

Pakpak-lawin is a large xerophyte, belonging to the fern family Polypodiaceae. Rhizome is creeping, stout and fleshy, with narrow, brown to blackish short-ciliate scales about 1 centimeter long. Leaves are of two kinds: cup-leaves and the fertile fronds. Cup-leaves are humus gathering fronds, brown and shiny when mature, ovate, coriaceous, somewhat imbricate, 15 to 30 centimeters long, 5 to 20 centimeters wide, concave, shallowly lobed below and deeply so above. Fertile fronds are long, pinnately lobed, on stipes 20 to 30 centimeters long. Sori are 40 to 120 centimeters in length; lobes are rather large and arranged in tow rows between the main veins.

Throughout the Philippines, in primary and secondary forests, growing on rocks, trees, old stone walls.

- Phytochemical screening yielded phenols, tannins, alkaloids, proteins, xanthoproteins, carboxylic acid, coumarins and saponins.
- Yields catechin, coumarins, flavonoids, phenolics, saponin, steroids, tannins, and triterpenes.
- Study of dried rhizomes yielded friedelin, epifriedelinol, ß-amyrin, ß-sitosterol 3-beta-D-glucopyranoside and naringin. (10)
- Phytochemical analysis of fertile fronds yielded the presence of coumarins, flavonoids, glycosides, phenolics, saponins, steroids, tannins, and terpenoids. Total phenolic content was 186 mg/g equivalent of gallic acid. (see study below) (16)
- Phytochemical screening of rhizomes yielded steroids, phenolic group, catechins and tannin, with an absence of saponin and alkaloid. (see study below) (21)

- Study of petroleum ether extract of rhizome powder yielded phytosterols and fixed oils and fats. Chloroform extract yielded sterols; a methanolic extract yielded alkaloids, sterols and tannins; and a water extract yielded tannins, proteins, amino acids, carbohydrates, gums, and mucilage. (22)

- Studies have suggested antibacterial, antipyretic, antioxidant, anti-inflammatory, analgesic, anti-dermatophytic, CNS depressant, pesticidal, anthelmintic, repellent, hepatoprotective, hypoglycemic, hypolipidemic properties.

Parts utilized
Rhizomes and leaves.

· Decoction of fresh or dried rhizome for hemoptysis.
· Used as an astringent or antihelmintic.
· Decoction of rhizome used for fever.
· The leaves are used as poultices. Also used for dyspepsia, phthsis and fever.
· In Tamil, Nadu used to treat arthritis.
· In Bangladesh, rhizomes used in the treatment of excited mental disorders. Mixed with the plant Asparagus racemosus, applied to the head for calming effect and to reduce hair loss.
· In
Thai traditional medicine, used as diuretic.

Study of extracts of DQ showed high efficiency of antibacterial activity, especially to Gram negative bacteria. (1)
Anti-gonorrheal: In preliminary studies on activity of Ocimum sanctum, Drynaria quercifolia, and Annona squamosa against Neisseria gonorrhea, D. quercifolia showed activity against N gonorrhea comparable to penicillin and ciprofloxacin. (2)
Antipyretic / Rhizomes: Study of the extracts of rhizomes of D. quercifolia in rabbits showed antipyretic activity with significant reduction of elevated body temperature, comparable to aspirin.
Antioxidant: Study of a methanolic extract of powdered rhizome of Drynaria quercifolia by DPPH assay showed it to be an effective antioxidant compared to other extracts, with significant activity compared to standard drug. (4) In a study screening fifteen fern species for antioxidant activity, Drynaria quercifolia was one of five that showed antioxidant properties with strong DPPH radical scavenging activity, ferric ion reducing power, and inhibition of lipid peroxidation. (9)
Anti-Inflammatory / Analgesic: Study of the ethanolic extract of the rhizome of D. quercifolia on Wistar rats showed potent anti-inflammatory and analgesic activity comparable to indomethacin, sodium salicylate and aspirin. Results justify its use for alleviating painful inflammatory conditions. (5)
Antidermatophytic / Rhizomes: Study was done on the dermatophytic activity of four rhizome extracts from D. quercifolia against T. mentagrophytes, M. canis, T. rubrum and e. floccosum. Results showed the ethyl acetate extract contains triterpenes and coumarins which may be the compounds responsible for the antidermatophytic activity of this plant. (6)
Antibacterial / 3,4- dihydroxybenzoic acid / Rhizome: Study isolated 3,4- dihydroxybenzoic acid from the rhizome of D. quercifolia which showed significant antibacterial activity against four gram-positive and six gram-negative bacteria. (7)
CNS Depressant Effect: Study in mice of ethanol extract fractions of rhizome of D. quercifolia showed a dose-dependent depressant effect. (13)
Antibacterial / Dried Rhizome: Study of dried rhizome yielded friedelin, epifriedelinol, ß-amyrin, ß-sitosterol, ß-sitosterol 3-beta-D-glucopyranoside, and naringin. The methanol extract showed broad and concentration-dependent antibacterial activity. (10)
Antibacterial Efficacy Against Urinary Tract Pathogens: Various extracts were tested for antibacterial activity against clinically isolated urinary tract pathogens. An acetone extract was effective against Enterococcus faecalis and Streptococcus pyogenes while an ethanol extract was effective against Pseudomonas aeruginosa. (11)
Antihelmintic: Study evaluated the anthelmintic potential of D. quercifolia against adult earthworms and piperazine citrate as standard. Results showed anthelmintic potency of the extract, inversely proportional to the time taken for paralysis and death of the worms. (12)
Antibacterial / Cytotoxicity: Various extracts were tested for antibacterial activity and cytotoxicity. Results showed antibacterial activity against four gram-positive and six gram-negative bacteria. Extracts showed cytotoxicity using brine shrimp lethality bioassay.
Ameliorative Effect in Rheumatism: Study evaluated the anti-arthritic effect of a rhizome water extract. Results showed reduction of paw thickness and elevation of mean body weight of arthritic rats, with significant reduction of plasma and liver lysosomal enzyme and levels of serum pro-inflammatory cytokines (TNF-a and IL-1ß and increment of anti-inflammatory cytokine (IL-10) with treatment. (14)
Antioedematous / Analgesic / Fertile Fronds: Study evaluated the antioedematous, antiproliferative, and analgesic properties of ethanolic extract of fertile fronds of D. quercifolia. There was significant inhibition of carrageenan and histamine induced paw edema in Wistar rats. The fertile fronds significantly attenuated acute and delayed phased of formalin induced pain, acetic acid-induced writhing, capsaicin-induced nociception, and hot plate test in mice. (see constituents above) (16)
Pesticidal / Repellent / Tribolium castaneum: Study of a chloroform fraction of D. quercifolia rhizomes extract showed significant pesticidal and pest repellency activities. (17)
Hepatoprotective: / Fronds: Study of a hydroalcoholic extract of D. quercifolia fronds, its fractions, and isolated compound (Dq-r) on carbon tetrachloride induced hepatotoxicity showed significant dose-dependent hepatoprotective activity. (18)
Antidiabetic / Hypolipidemic: Ethanolic and chloroform extracts of Drynaria quercifolia rhizome in STZ-induced diabetic rats showed significant antidiabetic and hypolipidemic property. Glibenclamide was used as reference standard. (19)
Antioxidant / Cytotoxic / Antimicrobial: Study evaluated various extracts from sun-dried rhizomes for antioxidant, cytotoxic, and antimicrobial activities of whole plant of D. quercifolia. Results showed very potent anti-oxidant activity by DPPH assay, mild antimicrobial activity, and cytotoxic potential using brine-shrimp lethality bioassay. (20)
• Antimicrobial: Preliminary phytochemical screening yielded steroids, phenolics, catechins and tannin. Ethanolic extract of rhizomes showed antifungal and antibacterial properties. (21)
• Bone Regenerative / Treatment of Periodontal Intrabony Defects: Study evaluated the effect of Drynaria quercifolia rhizome extract as bone forming substitute in periodontal intraosseous defects. Study involved twenty patients with chronic periodontitis with intraosseous defects. Control group was treated with open flap debridement (OFD) while the treatment group had OFD and placement of drynaria plant extract. Probing pocket depth reduction (PPD) and relative attachment level gain after six months were more for the treatment group, the difference statistically significant. Results suggest the rhizome extract has potential regenerative effect on bone cells; one of the effect probably mediated by an effect on osteoclast attachment. (23)
• Anti-Ulcer / Leaves: Study evaluated ethanol extract of leaves of D. quercifolia for anti-ulcer activity against pylorus ligation and ethanol induced ulcer models in experimental rats. Results showed significant (p<0.05) reduction in gastric volume, free acidity and ulcer index. The antiulcerogenic activity was attributed, possibly, to its antisecretory activity. (24)
• Cataractostatic Activity / Tuber: Study evaluated the cataractostatic activity of methanolic and ethyl acetate extracts of Drynaria quercifolia tuber as a prospective treatment for lens catartacts using a glucose-induced cataract in isolated goat lenses in an in-vitro model. Results showed the EA extract of tuber was able to inhibit cataractogenesis. Study results suggest a potential cataractostatic agent to prevent diabetic cataract. (25)
• Membrane Stabilizing / Antioxidant / Thrombolytic / Rhizomes and Fronds: Study evaluated methanol extracts and fractions of dried rhizomes and fronds for membrane stabilizing, antioxidant and thrombolytic activities. ME of rhizomes and aqueous fractions showed potent DPPH and ABTS radical scavenging activity. Crude ME of rhizomes and fronds showed effective stabilization of erythrocyte membrane in hypotonic solution. ME and aqueous fraction of rhizomes showed noticeable clot lysis.    (26
• Synergism with Antimicrobials: Study evaluated the antimicrobial effect of an ethanol crude extract  of D. quercifolia rhizome against Staphylococcus aureus, S. epidermis, Pseudomonas aeruginosa and Eshcerichia coli. The crude extract alone did not show any zone of inhibition. However, a synergistic effect was observed when used with ampicillin and oxytetracycline against S. aureus. In vivo testing in Sprague-Dawley rats also showed the same synergistic effect with p-value of 0.047. (27)

Ornamental cultivation.

© Godofredo U. Stuart Jr., M.D. / StuartXchange

Updated July 2018 / January 2016

Photo © Godofredo Stuart / StuartXchange
OTHER IMAGE SOURCE: Drynaria quercifolia / Modified from Richard Wettstein - Handbuch der Systematischen Botanik (1924) - Permission granted to use under GFDL by Kurt Stueber. Source: www.biolib.de / GNU Free Documentaion License / alterVISTA

Additional Sources and Suggested Readings
Drynaria quercifolia (L.) J.Sm: A potential resource for antibacterial activity
African Journal of Microbiology Research Vol.(2) pp. 202-205, August, 2008 / M. Kandhasamy, K. D. Arunachalam and A. J. Thatheyus
Preliminary studies on activity of Ocimum sanctum, Drynaria quercifolia, and Annona squamosa against Neisseria gonorrhoeae / SHOKEEN Poonam; RAY Krishna; BALA Manju; TANDON Vibha /
Antipyretic Activity of Rhizome of Drynaria quercifolia. in Rabbit / Alam Khan, Ekramul Haque, et al / Pharmaceutical Biology, 2007, Vol. 45, No. 4, Pages 312-315

/ Arun Kumar Beknal, Prakash Korwar et al / International Journal of CURRENT PHARMACEUTICAL RESEARCH
ISSN- 0975-1491 Vol 2, Issue 4, 2010
Anti-inflammatory and analgesic properties of Drynaria quercifolia (L.) J. Smith. / G I Anuja, P G Latha, S R Suja, S Shyamal et al / J Ethnopharmacol 132(2):456-60 (2010
Anti-dermatophytic activity of Drynaria quercifolia (L.) J. Smith / Batool Sadeghi Nejad, Subhash Sadhu Deokule / Jundishapur Journal of Microbiology (2009); 2(1): 25-30
Isolation of antibacterial constituent from rhizome of Drynaria quercifolia and its sub-acute toxicological studies / Khan A,, Haque E et al / DARU Vol. 15, No. 4 2007
Drynaria quercifolia (L.) J. Sm. / Chinese name / Catalogue of Life, China
Evaluation of Antioxidant Activities of the Methanolic Extracts of Selected Ferns in Malaysia / HowYee Lai and YauYan Lim / International Journal of Environmental Science and Development, Vol. 2, No. 6, December 2011
Phytochemical and antimicrobial studies on Drynaria quercifolia. / Ramesh N, Viswanathan MB, Saraswathy A, Balakrishna K, Brindha P, Lakshmanaperumalsamy P. / Fitoterapia. 2001 Dec;72(8):934-6.
Antibacterial efficacy of Drynaria quercifolia (L.) J. Smith (Polypodiaceae) against clinically isolated urinary tract pathogens / Muraleedharannair Jalajakumari Mithraja, Varaprasadham Irudayaraj, Solomon Kiruba, Solomon Jeeva / Asian Pacific Journal of Tropical Biomedicine (2012)S131-S135 S131
Anthelmintic activity of Drynaria quercifolia (L.) J. Smith. / Gauri Kaustubh Kulkarni, Renuka V. Kadolkar, Amit B. Maisale / Journal of Pharmacy Research, Vol 3, No 5 (2010)
Neuropharmacological Effect of the Rhizome of Drynaria quercifolia in Mice / Alam Khan, Ekramul Haque, BYTUL M RAHMAN, MATIUR RAHMAN / Iranian Journal of Pharmacology & Therapeutics, Vol 8, No 1 (2009)
Ameliorative effect of Drynaria quercifolia (L.) J. Sm., an ethnomedicinal plant, in arthritic animals / Saravanan S, Mutheeswaran S, Saravanan M, Chellappandian M, Gabriel Paulraj M, Karunai Raj M, Ignacimuthu S, Duraipandiyan V. / Food Chem Toxicol. 2012 Oct 26;51C:356-363. / doi: 10.1016/j.fct.2012.10.020.
Drynaria quercifolia / Synonyms / The Plant List
Antioedematous and Analgesic Properties of Fertile Fronds of Drynaria quercifolia / G. I. Anuja, P. G. Latha, V. J. Shine, S. R. Suja, P. Shikha, K. Satheesh Kumar, and S. Rajasekharan / ISRN Inflammation
Volume 2014 (2014) / http://dx.doi.org/10.1155/2014/302089
Pesticidal and pest repellency activities of rhizomes of Drynaria quercifolia (J. Smith) against Tribolium castaneum (Herbst) / Alam Khan, *; Md Hedayetul Islam; Md Ekramul Islam; Md Abdul Alim Al-BarI; Mst Shahnaj Parvin; Mohammed Abu Sayeed; Md Nurul Islam; Md Ekramul Haque / Biol. Res. vol.47 Santiago 2014 / http://dx.doi.org/10.1186/0717-6287-47-51
Hepatoprotective Effect of Drynaria quercifolia Fronds Hydroalcoholic Extract and Isolated Constituent against CCl4-Induced Hepatocellular Damage / Pradeep Kamboj* and Ajudhia Nath Kalia / British Journal of Pharmaceutical Research, ISSN: 2231-2919,Vol.: 3, Issue.: 4 (October-December)
Evaluation of Antidiabetic and Hypolipidemic Potential of Drynaria quercifolia Linn Rhizome in Streptozotocin Induced Diabetic Rats / Rajimol E K*, Shan P Mohammed, Nasiya Latheef, P Sriganesan / Int. J. Pharm. Sci. Rev. Res., 25(1), Mar – Apr 2014; Article No. 20, Pages: 118-124
Evaluation of Antioxidant, Cytotoxic, and Antimicrobial Properties of Drynaria quercifolia / Milon Chandra Mohanta, Avijit Dey, S M Abdur Rahman, Rezwna Nazreen Chowdhury / International Research Journal of Pharmacy, 2013, 4(7)
Pharmacognostical studies on a medicinal fern Drynaria quercifolia (L.) J. Sm. (Polypodiaceae: Pteridophyta) / V Irudayaraj, R Senthamarai / Phytomorphology: An International Journal of Plant Morphology, July 2004; 54(3): pp 193-200
A STUDY ON PHYTOCHEMICAL INVESTIGATION OF DRYNARIA QUERCIFOLIA LINN RHIZOME / Prakash G. Korwar, Arun Kumar Beknal, Basawaraj S. Patil, M. A. Halkai, Upendra Kulkarni, Hariprasanna R. C.  and Srinivas R. Soodam / International Journal of Pharmaceutical Sciences and Research
Drynaria Quercifolia Plant Extract as A Bone Regenerative Material in The Treatment of Periodontal Intrabony Defects: Clinical And Radiographic Assessment / Dr Varsha Pawar, Dr K. T. Chandrashekar, Dr Rohit Mishra, Dr Vandana Tripathi, Dr Kaushal Tripathi / IOSR Journal of Dental and Medical Sciences (IOSR-JDMS), March. 2017; Volume 16, Issue 3, Ver. VI: pp 93-99
Anti ulcer activity of ethanolic extract of Drynaria quercifolia Linn. leaves / D Soni, Jagan Mohan K, Sai Goud A, V R Krishna Raju Mantena / Journal of Pharmacy Research, 2012; 5(1): pp 117-119
Cataractostatic Activity of Drynaria quercifolia Tuber Extract
/ Md. Miraj Kobad Chowdhury, Md. Jakir Hossain, M Aftab Uddin* / Bioresearch Communications, July 2017; Vol 3, Issue 2
In vitro membrane stabilizing, thrombolytic and antioxidant potentials of Drynaria quercifolia L., a remedial plant of the Garo tribal people of Bangladesh
/ Farjana Rahman ChaityMahbuba Khatun and Mohammad Sharifur Rahman / BMC Complementary and Alternative Medicine, 2016; 16:184 / https://doi.org/10.1186/s12906-016-1170-5
THE SYNERGISTIC ACTIVITY OF THE ETHANOLIC EXTRACT OF DRYNARIA QUERCIFOLIA (POLYPODICEAE) WITH OXYTETRACYCLINE AND AMPICILLIN ON SELECTED GRAM POSITIVE AND GRAM NEGATIVE BACTERIA / Carmelus Francis Rebagay Aseneta, Jessica Mae Panaguiton Manansala, Nathaniel Samir Martinez, Vince Trevelyan Villanueva Sicat, Ma. Sheila Magalonzo De Jesus / BIOTA Philippines Conference System, 48th BIOTA Annual National Convention and Scientific Sessions

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