Ulasiman-kalat is a slender, spreading or ascending,
smooth, more or less branched, annual herb, reaching a length or 50 centimeters
or less. Leaves are linear and 1 to 3 centimeters long. Flowers are white, 3 millimeters long and occurring singly in the
axils of the leaves. Pedicels are about as long as the calyx. Corolla
lobes are entire. Ovary is 2-celled. Fruits are capsules, loculicidal, ovoid, about 4 millimeters long
and do not protrude beyond the calyx segments.
- A common weed in and about towns and in waste places, gardens and open lands throughout the Philippines.
- Also occurs in India to Japan and Malaya.
· Entire plant.
· Harvest the entire plant from April to September.
· Wash and sun-dry.
- Yield flavones, anthraquinones, polysaccharides.
- Study yielded a four anthraquinones, triterpenoids (ursolic acid and oleanolic acid).
- Study of chemical constituents yielded anthraquinones, terpenoids, flavonoids, steroid alchols, alkanes, organic acids, polysaccharides, coumarin and alkaloids.
- Study of nine compounds: 2, 6-dihydroxy-1-methoxy-3-methylanthraquinone, 2-hydroxy-1-methoxy-3-methylanthraquinone, 2-hydroxy-3-methylanthraquinone, quercetin-3-O-[2-O-(6-O-E-sinapoyl)-beta-D-glucopyranosyl]-beta-glucopyranoside, quercetin-3-O-[2-O-(6-O-E-feruloyl)-beta-D-glucopyranosyl]-beta-glucopyranoside, kaempferol-3-O-[2-O-(6-O-E-feruloyl)-beta-D-glucopyranosyl]-beta-galactopyranoside, quercetin-3-O-(2-O-beta-D-glucop-yranosyl)-beta-D-glucopyranoside, rutin, and quercertin.
- Sweet tasting, cooling in effect.
- Considered alterative, antibacterial, antidote, analgesic, antiinflammatory,
antitumor, diuretic, febrifuge and sedative.
· For any kind of inflammation,
e.g., tonsillitis, laryngitis, and appendicitis: use dried preparation
30 to 60 gms (or fresh material 120 to 240 gms) boil to decoction and
· Used for jaundice and hepatitis, malignant tumors.
· Poultice of plant material used for external bruises or blood
congestions, boils, and abscesses.
· Plant decoction used for biliousness, fever and gonorrhea.
· Used for fevers, cough, asthma.
· In Chinese folk
medicine, used in hepatitis and malignant tumors of the liver, lung
and stomach. Also used for carbuncles, skin sores and ulcerations, tonsillitis, painful
swollen throats, appendicitis, urethral affections, gynecologic infections, and snake bites.
Study yielded five flavonol glycosides and four O-acylated iridoid glycosides.
All nine compounds exhibited neuroprotective activity in cultures of
damaged rat cortical cells.
• Antitumor: Although
used in folk medicine for malignant tumors of the liver, lung and stomach,
study showed no antiproliferative or antiangiogenic effects to support
its folkloric antitumor use.
• Immunocompetent Activity:
Study showed H diffusa improved the leukopenia and splenic cellular
decrease caused by irradiation and increased the immunocompetence of
splenic cells after mitogenic stimulation. Study suggests H diffusa
may be effective in preventing hematopoietic damage in combination use
with radiotherapy. (3)
• Antioxidant: In
a study of H diffusa, H corymbosa and M pentaphylla, all three showed
varying levels of antioxidant and radical scavenging activities.
• Phytochemicals: Study isolated five flavonoids from H diffusa: kaempferol, kaempferl 3-O-beta-D-glucopyranoside, kaempferol 3-O-(6"-O--L-rhamnosyl)-beta-D glucopyranoside, quercetin 3-O-(2"-O-beta-D-glucopyranosyl)-beta-D-glygopyranoside.
• Anticancer: Study of OD extract against eight cancer cell lines showed strong antiproliferative activity against all cancer cell lines and induced significant increase of apoptosis. Also, there was significant inhibition of lung metastases in the animal model without noticeable side effects. Results suggest a potential for an anticancer agent.
• Methylanthraquinone / Anticancer: Study yielded methylanthraquinone from Hedyotis diffusa which exhibited potent anticancer activity. In a study in human breast cancer cells, results suggested that methylantrhaquinone induced MCF-7 cells apoptosis via Ca2+/calpain/caspase-4-pathway. (7 )
• Antitumor / Phytotoxic: Study of leaf methanol extract of Oldenlandia diffusa showed tumor inhibition on potato disc and significant phytotoxicity. Results suggest Oldenlandia diffusa might be a potential source of antitumor agent for use in the treatment of tumors in human. (8)
• Oleanolic Acid / Fibroblast Inhibition / Chemopreventive / Chemotherapeutic: Study showed oleanolic acid inhibited the growth of ras oncogene-transformed R6 cells at doses not toxic to normal fibroblasts. Results demonstrate oleanolic acid possess both cancer therapeutic and chemopreventive activities and presenting a great potential as a novel anti-cancer drug. (9)
• Cytotoxicity: Study sought to identify the most cytotoxic constituents of a water extract. Results suggest certain constituents, possibly including ursolic/oleanolic acid, may be bioavailable and at sufficient concentration induces apoptosis in cancer cells through mechanisms including the cleavage of PARP. (12)
• Corymbosa Vs Diffusa: A systematic survey showed O. corymbosa to be used indiscriminately as O. diffusa. Study showed the oleanolic acid and ursolic acid contents in O. diffusa were lower than O. corymbosa. (13)
• Evidence- Based Perspective For Cancer: About 15% of anticancer herbal concoctions used in China contain H. diffusa. Preclinical and clinical studies have established safety and efficacy for certain cancers. It can inhibit growth of some cancer cells, induce apoptosis in vitro and in vivo, exhibit selective cytotoxicity. It has immune modulation functions against cancer, and enhances natural killer cells and macrophage activities. (14)
• Apoptosis / Burst-Mediated Caspase Activation: Study of ethanol extract showed dose-dependent inhibition of cancer cell growth in MTT assay. The cancer cell apoptosis was probably through burst-mediated caspase activation. (15)
• Ulcerative Colitis: Study investigated the protective effect of Oldenlandia diffusa in dextran sulfate sodium (DSS)-induced colitis. OD attenuated clinical signs and suppressed levels of interleukin IL-6, IL-1ß and expression of COX-2 in DSS-treated colon tissues. Results suggest a potential experimental medicine for patients with ulcerative colitis. (16)
• Antiproliferative / Apoptotic / Breast Cancer: Study showed OD and its bioactive compounds exert antiproliferative and apoptotic effects selectively in ERa-positive breast cancer cells, suggesting a potential for preventive or therapeutic use. (17)
• Tumor Inhibition: Study evaluated the key components exhibiting anti-tumor activities in the two herbs, Hedyotis corymbosa and H. diffusa using plant components ursolic acid, oleanolic acid, and geniposidic acid. Results showed ursolic acid and oleanolic acid to inhibit the growth of cultured hep-2B cells and enlargement of subcutaneous tumor. (18)
• Anti-Inflammatory / Hepatoprotective / Peh-Hue-Juwa-Chi-Cao: Study in rats evaluated Peh-Hue-Juwa-Chi-Cao, containing extracts of Hedyotis diffusa, H. corymbosa or Mollugo pentaphylla. Results showed all three possess anti-inflammatory activity and hepatoprotective properties, reducing acute elevation of SGOT and SGPT after intraperitoneal administration of hepatotoxins. (19)
• Hepatoprotective / LPS-Induced Liver Damage: Study evaluated the hepatoprotective effects of HD against lipopolysaccharide-induced liver damage in Sprague-Dawley rats. Results showed hepatoprotective activity attributed, in part, to its antioxidant activity. (20)
• Tumor Angiogenesis: Study evaluated the angiogenic effects of an ethanolic extract of H. diffusa. Results showed in vivo inhibition of angiogenesis in chick embryo chorioallantoic membrane and dose-time-dependent inhibition of proliferation of human umbilical vein endothelial cells by blocking of cell cycle progression. EEHDW also down regulated the mRNA and protein esxpression levels of VEGF-A in HT029 human colon carcinoma and HUVECs.Results suggest inhibition of tumor angiogenesis is one of the mechanisms by which H. diffusa is involved in cancer therapy. (21)
Extracts in the cyber market.