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Family Boraginaceae
Tapiasin
Coldenia procumbens Linn.
CREEPING COLDENIA

Shuang zhu zi cao

Scientific names Common names
Coldenia procumbens Linn. Oreganong-lalaki (Tag.)
  Papait-ti-nuang (Ilk.)
  Tabata-bokol (Ilk.)
  Tapiasin (Tag.)
  Creeping coldenia (Engl.)
  Shuang zhu zi cao (Chin.)

Other vernacular names
COUNTRY: Name
CHINESE: Shuang zhu zi cao.
HINDI: Tripunkee, Tripungki, Tripunkhi.
MARATHI: Tripunkhi, Taipakshi.
KANNADA: Hamsapaadi, Godaapadi.
SANSKRTI: Trupakshee, Tripakshi.
TAMIL: Seruppadai, Sirupai, cheruppadi.
THAILAND: Yaa teentukkae, Yea Teentukto, Yaa tupto.
VIETNAM: C[as]p di[eef]n.

Botany
Tapiasin is an annual, hairy herb. Branches are procumbent, spreading flat on the ground, and growing as long as 25 centimeters. Leaves are elliptic to oblong-obovate and 1.5 to 2.5 centimeters long, with coarsely toothed margins, blunt tip, and a very unequal base. Flowers are white and small, and borne in the axils of the leaves. Sepals are four, narrow, with four lobes which are imbricate in bud. Fruit is conical, 3 to 4 millimeters in diameter, containing four 1-seeded pyrenes.

Distribution
- Found in Cagayan, La Union, Pangasinan, Zambales, Pampanga, and Rizal Provinces in Luzon; and in Mindoro, in dry open places, fallow rice paddies, etc. at low and medium altitudes.
- Now, pantropic.

- Widespread in tropical and subtropical Africa, Asia and Australia.

Constituents
- Phytochemical screening of leaves yielded alkaloids, flavonoids, carbohydrates, and phenolic compounds. (1
1)

Parts used
Leaves, juice, aerial parts.

Uses

Folkloric
- In the Philippines, leaves are applied as poultice to mature abscesses.
- Dried leaves, when pulverized, provoke sneezing.
- In India, fresh leaves are ground up and applied to rheumatic swellings. Leaves applied externally to cause suppuration of boils. Leaves also used for fever, piles, and scorpion stings. Powdered roots are included in formulations used for leucorrhea and menorrhagia. Root decoction used as aid for digestion.
- In Tamil Nadu, juice of leaf taken orally to prevent white discharge in women.
- In southern India, a herbal concoction made with a mixture of leaves of C procumbens, flowers of Ixora coccinia, leaves of Centella asiatica and stem bark of Madhuca longifolia is boiled in water and the decoction applied topically with coconut oil for wound healing.
- Decoction of aerial parts used for tendonitis.

Studies
Antidiabetic:
Study of C. procumbens on alloxan-induced diabetic rats showed the test drug to have good hypoglycemic effects. Results showed reduction of blood glucose, triglycerides and cholesterol levels. (1)
Anti-Inflammatory: Ethanolic extract of the aerial parts of C. procumbens exhibited significant anti-inflammatory activity with inhibition of carrageenan-induced rat paw edema and inhibition of leukocyte migration and reduction of pleural exudates
in the cotton pellet granuloma method. (2)
Antibacterial: (1) Study of aqueous extract showed antibacterial activity against B. subtilis, S. aureus, E. coli, P. aeruginosa, P. vulgaris and K. pneumonia in comparison with standard drug ciprofloxacin. (6)
Antibacterial / Leaves: Ethanolic extracts of leaf of C. procumbens showed significant antibacterial activity against S. aureus, Strep pyrogenes. (7)
CNS Depressant Effects / Analgesic: Alcoholic extract of whole plant produced central nervous system depression and significant prolongation of pentobarbitone sleeping time. The extract also exhibited significant analgesic effect. (8)
Antioxidant / Leaves: Study evaluated the in vitro antioxidant activity of ethanolic extract of C. procumbens by DPPH and Nitric oxide radical inhibition activity assays. Results showed promising results. Standards used were ascorbic acid and rutin. (10)
Anthelmintic / Leaves: Study evaluated various extracts of leaves for anthelmintic activity against earthworm Pheretima Posthuma. Ethanolic and aqueous extracts showed potent anthelmintic activity compared with Albendazole. (11)
Hepatoprotective / D-Galactosamine Induced Liver Injury: Study evaluated a chloroform extract of whole plant for hepatoprotective activity against D-Galactosamine induced liver injury in rats. Results showed significant reversal of biochemical changes. (13)
Antimicrobial / Leaves: Study evaluated ethanol extracts of Heliotropium indicum and Coldenia procumbens for antimicrobial activity against S. aureus, B. subtilis, Strep pyogenes, P. aeruginosa, K pneumonia, Aspergillus niger, T. viride and Candida albicans. Results showed the leaf extract to showed the highest activity against both bacteria and fungi. H. indicum leaf extract showed highest inhibitory activity. (15)

Availability
Wild-crafted.

Last Update January 2014

IMAGE SOURCE: Photo / File:Coldenia procumbens in AP W IMG 9943.jpg / J M Garg / 05.07.08 / GNU Free Documentation / click on image to go to source page / Wikimedia Commons
OTHER IMAGE SOURCE: Photo / File:Coldenia procumbens in AP W3 IMG 9943.jpg / J M Garg / 05.07.08 / GNU Free Documentation / click on image to go to source page / Wikimedia Commons

Additional Sources and Suggested Readings
(1)
Evaluation of Antidiabetic Activity of Coldenia procumbens in Alloxan-Induced Diabetes in Rat / Nita Patel, Sunant Raval et al / Journal of Herbal Pharmacotherapy,
2007, Vol. 7, No. 1 , Pages 13-23
(2)
ANTI-INFLAMMATORY ACTIVITY OF COLDENIA PROCUMBENS LINN. / B Arul, R Kothai et al / Pakistan Journal of Pharmaceutical Sciences, Vol. 18, No.3, July 2005, pp.17-20
(3)
Medicinal plants used by traditional healers in Kancheepuram District of Tamil Nadu, India / Chellaiah Muthu, Muniappan Ayyanar et al /Journal of ethnobiology and ethnomedicine, Vol 2, 2006
(4)
Herbal medicines for wound healing among tribal people in Southern India: Ethnobotanical and Scientific evidences / Ayyanar M, Ignacimuthu S / International Journal of Applied Research in Natural Products
Vol. 2(3), pp. 29-42, Sep-Oct 2009
(5)
PHARMACOGNOSTICAL STUDIES ON LEAF OF Coldenia procumbens Linn / R. SENTHAMARI, M.UVARANI, B. JAYAKAR / Ancient science of life Vol: XXII (1) July /2002
(6)
Antibacterial Activity of Coldenia Procumbens Linn . / Mrs. BEEN AP. / Ancient Science of Life Vol: XXIV (3) January, February, March - 2005
(7)
in vitro Antibacterial Activity of different extracts of Leaves of Coldenia procumbens / G. Ramakrishnan, R. Kothai, B. Jaykar, T. Venkata Rathnakumar / IJPRIF, Vol. 3, No.2, pp 1000-1004, April-June 2011
(8)
Central nervous system effects of Coldenia procumbens / MA Nagarani, V Vijayasekaran, Kameswaran Lalitha / Indian Journal of Pharmacology, 1991, Vol 23, No 4, Pp 261-263.
(9)
Creeping Coldenia / Common names / Flowers of India
(10)
In Vitro Anti Oxidant Study of Ethanolic Extract of Coldenia procumbens Linn / Beena, P.; Purnima, S.; Kokilavani, R.. / Asian Journal of Research in Chemistry . Mar2011, Vol. 4 Issue 3, p450-451. 2p. 2 Charts.
(11)
Invitro anthelmintic activity of different extracts of Coldenia procumbens / Aleemuddin MA, Karthikeyan M, Krishna Priya P l/ J. Nat. Prod. Plant Resour., 2012, 2 (2):267-271
(12)
Review: COLDENIA PROCUMBENS LINN - A PHYTOPHARMACOLOGICAL REVIEW / *Aleemuddin. MA, Karthikeyan.M, Rajasekar.S / International Journal of Pharmaceutical Sciences Review and Research, Volume 11, Issue 2, November – December 2011
(13)
HEPATOPROTECTIVE EFFECT OF COLDENIA PROCUMBENS LINN AGAINST D-GALACTOSAMINE INDUCED ACUTE LIVER DAMAGE IN RATS / R.GANESAN* et al / International Journal of Integrative sciences, Innovation and Technology, Int. J. Int sci. Inn. Tech. Sec. B, Apr. 2013, Vol.2, Iss 2, pg 9-11
(14)
Coldenia procumbens L. / Vernacular names / GLOBnbMED
(15)
Antimicrobial activity of Heliotropium indicum and Coldenia procumbens. / Boominathan, M.; Ramamurthy, V.
/ Journal of Ecobiology 2009 Vol. 24 No. 1 pp. 11-15


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