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Family Chrysobalanaceae
Atuna excelsa subsp. racemosa (Raf.) Prance

Scientific names Common names
Atuna elata (King) Kosterm.            Botga (Bikol)
Atuna excelsa subspracemosa (Raf.) Prance        Getabon (Tagbanua)
Atuna racemosa  Raf.            Tabon-tabon (Tagalog)
Atuna scabra (Hassk.) Kosterm.             
Chrysobalanus racemosus Roxb.             
Cyclandrophora elata (King) Kosterm.             
Cyclandrophora glaberrima Hassk.           
Cyclandrophora laurina (A.Gray) Kosterm.             
Cyclandrophora scabra (Hassk.) Kosterm.             
Ferolia glaberrima (Hassk.) Kuntze           
Ferolia scabra (Hassk.) Kuntze           
Parinari curranii Merr.           
Parinari elata King           
Parinari glaberrimum (Hassk.) Hassk.           
Parinari hahlii Warb.           
Parinari lanceolata Teijsm. & Binn.           
Parinari laurina A.Gray    
Parinari macrophylla Teijsm. & Binn.           
Parinari margarata A.Gray     
Parinari mindanaensis Perkins           
Parinari racemosa Merr.      
Parinari scabra Hassk.      
Parinari scabra var. lanceolata Koord. & Valeton  
Parinari scabra var. macrophylla Koord. & Valeton  
Parinari warburgii Perkins ex Merr.      
Petrocarya glaberrima (Hassk.) Miers     
Petrocarya scabra  (Hassk.) Miers     
Atuna excelsa subsp. racemosa (Raf.) Prance is an accepted name. KEW: Plants of the World Online
Atuna excelsa subsp. racemosa (Raf.) Prance is an accepted infraspecific of Atuna excelsa. KEW: Plants of the World Online
Atuna racemosa (Raf) is a synonym of Atuna excelsa subsp. racemosa (Raf.) Prance.

Other vernacular names
BORNEO: Belibu, Jagong-jagong, Kayung jaras, Kukut, Mahadiu, Merampangi, Senumpol, Tapu-tapu, Tatambu, Temalang, Torog.
INDONESIA: Atung, Iomo, Pele kambing.
MALAYSIA: Kukut, Membatu.
SAMOA: Ifiifi.
TRADE NAME: Merbatu.

Gen info
- Atuna is a genus of plants in the family Chrysobalanaceae described as a genus in 1838.
- Etymology: The specific epithet racemosa derives from Latin meaning "clustered", referring to the inflorescence.

- Archaeological snippet: Remains of halved tabon-tabon fruits along side cut fish bones have been recovered from Barangay archaeological excavation site in Butuan (c. 10th to 13th century AD) indicating the cooking practice of kilawin using tabon-tabon is almost a thousand years old. (3)

Atuna racemosa is a mid-canopy tree up to 31 m tall and 90 cm dbh. Stipules long and semi-persistent, especially conspicuous at the twig tip. Leaves alternate, simple, penni-veined. Flowers ca. 13 mm in diameter, white-yellowish, with long protruding anthers, placed in racemes.
Fruits ca. 58 mm long, brownish, drupe. (2)

- Native to the Philippines.
- Also native to Bismark Archipelago, Borneo, Caroline Is., Fiji, Malaya, Maluku, New Guinea, Samoa, Santa Cruz Is., Solomon Is., Sulawesi, Sumatera, Thailand, Tonga, Vanuatu, Wallis-Futuna Is.
- Grows primarily in the wet tropical biome.
- Found in mixed dipterocarp forests, in swamps and along rivers, from sea level to 750 mg altitude. (3)

- Phytochemical screening of ethanolic extract of inner bark yielded flavonoids +++, alkaloids +, saponins +++, tannins +++. steroids +++, with absence of cyanogenic glycosides and anthraquinones. (see study below) (4)
- Alkaloids, anthraquinones, flavonoids, phenols and saponins were all detected in the 1%, 3% and 5% acetic acid extracts of A. racemosa fruits. (see study below) (8)
- Thin Layer Chromatography showed the endocarp extract contains phenols, tannins, flavonoids, alkaloids, coumarins, anthranoids and indoles. (see study below) ) (11)

- Studies have suggest antibacterial, antioxidant, cytotoxicity, antiplatelet aggregation properties.

Parts used
Bark, leaves, roots.


- Fruits are edible.
- In the Philippines, fruits are traditionally used in the preparation of kinilaw (dish of raw fish in vinegar or citrus juices) to neutralize the fishy taste and acidity of the raw seafood dish. (3)
- No reported medicinal use in the Philippines.
- In Samoa, decoction of inner bark drunk to treat severe abdominal pains.
- In the Solomon Is. used for diarrhea.
- Leaves used for treatment of swellings and inflammation. Roots used for treating infection of the soles of feet. Inner bark used for treatment of hypertension. (4)
- Crafts: In Fiji, leaves used for thatching.
- Oil: Seeds yield an oil used as scent. The cotyledons yield a massage oil.
- Putty: Fruit used for making putty for sealing canoes.

Antibacterial / Antioxidant / Inner Bark:
Study of ethanolic extract of inner bark showed antioxidant potential by DPPH assay. Antibacterial assay showed activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia, Salmonella typhimurium, and Pseudomonas aeruginosa. (see constituents above) (4)
Effect of Kernel Maturity on Antibacterial Activity: Study showed the antibacterial properties differ at different stages of kernel maturity. Immature kernels have a lower minimal inhibitory concentration (MIC) than mature kernels. Also, there is a negative correlation between antibacterial property and cytotoxic properties i.e., a stronger antibiotic is less cytotoxic, suggesting there are two separate compounds with disparate characteristics. (5)
Anti-MRSA (Methicillin-Resistant Staphylococcus aureus) / Kernel / Clinical Trial: Study reports the effectiveness of A. racemosa extract against MRSA is on par with currently available last-line antibiotics. Results of the randomized Phase 1 clinical trial suggests the extract well tolerated for topical use in humans at doses 10 time greater than the minimal inhibitory concentration for MRSA. (6)
Hepatocytes Detoxify Atuna racemosa Extract: While traditional uses of Atuna racemosa suggest little indication for toxicity. Using jurkat T cells and HepG2 hepatocytes as model, the potential of the extract to target the liver was evaluated. Results suggest A. racemosa extract would likely be detoxified by the liver. Study suggests further invivo toxicological evaluation. (7)
Cytotoxicity by Brine Shrimp Lethality Assay (BSLA) / Fruits: Study evaluated the cytotoxic activity of fruit by brine shrimp extract with varying acetic acid concentrations i.e. 1%, 3% and 5%. Results showed aqueous acetic acid extracts of A. racemosa fruits were cytotoxic against brine shrimp nauplii. The percentage mortality of the nauplii is directly proportional to the concentration of the extracting solvent - percent mortality of brine shrimp nauplii exposed to 5% AA extract was statistically higher compared to 1% and 3%. (8)
Cytotoxicity by Brine Shrimp Lethality Assay (BSLA) / Shell and Seed: Study evaluated Atuna racemosa aqueous, ethyl acetate, methanol, and decocted shell and seed extracts for toxicity using BSLA. Results showed medium to highly toxic activity to brine shrimp nauplii at LC50 of 268.605 µg/mL (aqueous shell), 165.195 µg/mL (aqueous seed), 277.9 µg/mL (ethyl acetate shell), 419.919 µg/mL (EA seed),116.032 µg/mL (methanol shell), 92.0427 µg/mL (methanol seed), 482.78 µg/mL (decoction shell), and 121.111 µg/mL (decoction seed), respectively. The ethyl acetate and methanol extracts of seed showed good toxicological properties. (9)
Effect  of Storage on Oxidative Properties of Fruits: Study evaluated the effect of storage on antioxidative property of A. racemosa fruits. The antioxidative properties of aqueous acetic acid extracts were determined using DPPH radical scavenging and Reducing Power assay. Decrease in the DPPH inhibition and reducing power is more pronounced at ambient temperature (25°C) than at 4°C. Fruits stored under 4°C and ambient temperature (25°C) gave values for DPPH inhibition and reducing power activity in the order Day1>Day2>Day3. Results suggest anti- oxidative property of A. racemosa fruits is affected by storage temperature and duration. (10)
Antiplatelet Aggregation / Endocarp: Study of Atuna racemosa endocarp extract showed antiplatelet aggregation effect on platelet suspension. Flavonoids, tannins and phenols may be responsible for the antiplatelet aggregation activity. (see constituents above) (11)


February 2023

                                                 PHOTOS / ILLUSTRATIONS
IMAGE SOURCE: Photo - Chrysobalanaceae : Atuna excelsa / Fruiting twig / Copyright © 2011 by Leonardo L Co [ref. DOL33928] / Non-Commercial Use  / click on image to go to source page / Phytoimages.siu.edu
OTHER IMAGE SOURCE: Photo - Chrysobalanaceae : Atuna excelsa / Flower / Photograph taken with financial support from the Rufford Small Grants Foundation / Copyright © 2013 by P B Pelser & J F Barcelona (contact:pieter.pelser@canterbury.ac.nz) [ref. DOL62489] / Non-Commercial Use / click on image to go to source page / Phytoimages.siu.edu

Additional Sources and Suggested Readings
Atuna excelsa subsp. racemosa / KEW: Plants of the World Online

Atuna racemosa Rafin. / AsianPlantNet
Atuna racemosa / Wikipedia
Qualitative assessment of the antimicrobial, antioxidant, and phytochemical properties of the ethanolic extracts of the inner bark of Atuna racemosa / Jericho Nadayag, Mark Llyod G Dapar, Agnes T Aranas, Roland Anthony R Mindo, Cesar G Demayo et al / Pharmacophore, 2019; 10(1): pp 52-59 / ISSN: 2229-5402
Antibacterial properties and toxicity of Atuna racemosa extract depend on kernel maturity / Eric J Buenz, John E Tillner Jr, Paul Limburg, Brent A Bauer / Journal of Ethnopharmacology, 2007; 111(3): pp 592-597 / DOI: 10.1016/j.jep.2007.01.020
A randomized Phase 1 study of Atuna racemosa: A potential new anti-MRSA natural product extract / Eric J Buenz, Brent A Bauer, David J Schnepple et al / Journal of Ethnopharmacology, 2007; 114(3): pp 371-376 / DOI:10.1016/j.jep.2007.08.027
Mitochondrial involvement in Atuna racemosa induced toxicity
/ Eric J Buenza / Journal of Ethnopharmacology, 2007; 109(2): pp 304-311 / DOI: 10.1016/j.jep.2006.07.043
Brine Shrimp Lethality of Atuna racemosa Raf. (Chrysobalanaceae) Fruits Extracted with Varying Acetic Acid Concentrations / Aileen Ma Gabule Ang, Fritzie Gay Embrado Reyes / Asian Journal of Biological and Life Sciences, 2019; 8(1): pp 25-29 / DOI: 10.5530/ajbls.2019.8.4
Phytochemical screening and toxicity testing of Atuna racemosa Rafin. chrysobalanaceae shell and seed extracts / Jinebeth M Pacana, Van Ryan Kristopher R Galarpe / IJAAS: International Journal of Advanced and Applied Sciences, 2017; 4(11): pp 110-115 / ISSN: 2313-626X / DOI: 10.21833.ijaas.2017.011.017
Effect of Storage Temperature and Duration on the Antioxidative Property of Atuna racemosa Raf. Fruits
/ Aileen May Gabule Ang, Rebecca Celis Deocampo / Asian Journal of Biological and Life Sciences, 2019; 8(1) / DOI: 10.5530/ajbls.2019.8.6
Antiplatelet aggregation of tabon-tabon Atuna racemosa Rafin, (1838) endocarp extract / Andrea Marie O Go, Suzanne Joy L Lasdoce / Thesis/Dissertations - Oct 2013

DOI: It is not uncommon for links on studies/sources to change. Copying and pasting the information on the search window or using the DOI (if available) will often redirect to the new link page. (Citing and Using a (DOI) Digital Object Identifier)

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