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Family Scrophulariaceae
Malaanis
Scoparia dulcis

SWEET BROOMWEED
Zhu zai cao

Other scientific names  Common names   
Scoparia grandiflora Isisa (Ilk.)  Silhigop (Bis.) 
Scoparia ternata Kabug (C. Bis.  Escobilla amarga (Sp.)
Capraria dulcis Mala-anis (Pamp.)  Broomweed (Engl.)
Gratiola micrantha Saang-kabayo (Tag.)  Licorice weed (Engl.) 
  Sampalokan (Tag.)  Sweetbroom (Engl.)
  Tachin-karnero (Iv.) Zhu zai cao (Chin.)

Botany:
· Erect, much branched, smooth, herbaceous, or half-woody plant 25 to 80 cm in height.
· Leaves: opposite and whorled, lanceolate to elliptic or oblanceolate, 0.5 to 2 cm long, pointed at both ends and narrowed below the short stalk, and toothed in the margins.
· Flowers: while, small, very numerous, and in pairs; their stalks slender, and 1 cm long or less. Sepals 4 or 5, imbricate, corolla rotate, 4-fid, the throat bearded, lobes subequal, white stamens 4, subequal.

Distribution
Ubiquitouos weedIn throughout the settled areas in low to medium altitudes; along roadsides, sides of ditches, and other more or less shaded and moist places.

Parts utilized:
· Whole plant.
· Collected from April to June.
· Wash, cut into pieces, dry under the sun.

Properties and Constituents
• Sweet and has cooling nature.
• Considered antipyretic, diuretic, analgesic, antiinflammatory, antifungal, antibacterial,
• Considered by some as aphrodisiac.

Constituents
• Study yielded diterpenoids, flavonoids, tannins, alkaloids, triterpenes, hexaconasol, b-sitosterol, ketone, dulcitone and amellin.
• Triterpene and mannitol isolated from the roots; dulcitol from aerial parts. (Source)
• Phytochemical studies revealed acacetin, amellin, amyrin, apigenin, benzoxazin, benzoxalinone, betulinic acid, daucosterol, dulcidion . . among others. Also isolated were a flavone glycoside and a diterpene. (source)

Uses
Folkloric
· Cold and fever, enteritis, diarrhea, beriberi, edema, difficulty in urination: Use decoction of 15 to 30 gms dried material.
· Miliaria: Rub the squeezed juice from fresh plant.
· In India, China and Southeast Asia, used for pain, fever, dysentery, diarrhea, cough, bronchitis, hypertension, piles and insect bites.
· In Vietnam, used for snakebites and antidote for cassava intoxication. Also, for pimples, impetigo, ulcers and eczema.
· In India, used for gonorrhea, to induce labor, and diabetes.
· In China, used for herpes.
· In Burma and India, herb infusion used as mouthwash for infected gums.
· In Brazilian folk medicine, used for bronchitis, gastric disorders, hemorrhoids, insect bites, skin wounds..
Others
· In Trinidad's santowah ceremony, sweetbroom is used to sprinkle holy water.

Studies
Antioxidant: (1) Free Radical Scavenging Activity of Scoparia dulcis Extract: Study showed strong antioxidant acitivity corresponding to the reduction of hydroxyl radical generation, a possible rationale for the weeds observed therapeutic effects. (2) Study showed significant decrease in TBARS and hyperperoxides formation in the brain of rats suggesting a role in protection against lipid peroxidation induced membrane damage. Results suggest, in addition to its antidiabetic effect, SD possess antioxidant potential.
Antihyperglycemic / Anti-Diabetes: (1)Effect of an aqueous extract of Scoparia dulcis on blood glucose, plasma insulin and some polyol pathway enzymes in experimental rat diabetes: Study showed SD was effective in attenuating hyperglycemia in rats, possibly due to the decreased influx of glucoxe into the polyol pathway with increased activities of antioxidant enzymes and plasma insulin and decreased activity of sorbitol dehydrogenase. (2) Study showed the aqueous extract of Scoparia dulcis exhibited antihyperglycemic effect by attenuating biochemical alterations in streptozotocin-induced diabetic rats.
Cytoprotective / Insulin-Secretagogue Activity: Study showed significant decrease in blood glucose with significantly increased plasma insulin level with use of aqueous extract of S dulcis in STZ-induced diabetic rats. Other results showed its insulin secretagogue activity and protection against STZ-mediated cytotoxicity. The glucose lowering effect was associated with potentiation of insulin release from the pancreatic islets.
Anti-Ulcer: Study showed water extracts of S dulcis showed dose-dependent inhibition of indomethacin-induced gastric damage in rats validating its use in traditional medicine as an antacid and anti-ulcer agent.
Antioxidant: Protective role of Scoparia dulcis plant extract on brain antioxidant status and lipidperoxidation in STZ diabetic male Wistar rats. Study showed levels of peroxidation markers in the brain were significantly a role in protection against lipidperoxidation-induced membrane damage.
Antimicrobial / Antifungal: Phytochemical and antimicrobial study of an antidiabetic plant: Scoparia dulcis L.: Study of isolated fractions showed significant antimicrobial and antifungal activity against all tested organisms – S typhii, S aureus, E coli, B subtilis, P aeruginosa, P vulgaris and fungal strains (C albicans, A niger and F oxysporum).
Antitumor: Scopadulcic acid B (SDB), a tetracyclic diterpenoid isolated from S dulcis, inhibited the effects of a tumor promoter, inhibited phopholipid synthesis and suppressed the promoting effect of TPA on skin tumor formation. Its potency is stronger than other natural anti-tumor promoting terpenoids.
Antihyperlipidemic: Effect of Scoparia dulcis (Sweet Broomweed) in Streptozotocin Diabetic Rats: Study showed antidiabetic and antihyperlipidemic activity in normal and experimental diabetic rats.
NGF Activity: Acetylated Flavonoid Glycosides Potentiating NGF Action from Scoparia dulcis: Three new acetylated flavonoid glycosides were isolated, two of which showed enhancing activity of nerve growth factor-mediated neurite outgrowth.
Cytotoxicity: Study isolated four new diterpenes. Crude extracts and pure diterpenes suggested cytotoxicty.
Beta-glucoronidase Inhibitor: Study isolated three labdane-type diterpene acids: scoparic acid A, B and C. Scoporic acid A was found to be a potent beta-glucoronidase inhibitor.
Hepatoprotective / Antioxidant: Study isolated showed the hydroalcoholic extract of S dulcis exhibits significant hepatoprotective activity against carbon tetrachloride-induced liver damage in rats, an activity attributed to free radical scavenging activity.
Anti-Trypanosomal Immunosuppression / Immunological Boosting: Previous findings suggest T. brucei is immunosuppressive. Study showed Scoparia dulcis provides a measure of immunological boost during experimental T. brucei infection in rabbits.
Sympathomimetic Effects / Catecholamines: Study yielded both noradrenaline and adrenaline in the plant extract. The catecholamines may be responsible for the hypertensive and inotropic effects after parenteral administration of S dulcis extracts.
Anti-Urolithiasis: Study investigating the inhibition of calcium oxalate, calcium phosphate and calcium carbonate mineralization by five medicinal plants – A aspera, P leschenaultii, S amplexicaulis, Scoparia dulcis and A lanata – showed that increased intake of the fruit juices and seed extracts of the test plants would be helpful in urinary stone prophylaxis. The sequestering of the insoluble calcium salts by the fruit juices may be due to single or mixed ligand chelation by the hydroxyl acids present in them.
Anti-Inflammatory / Analgesic: Study results indicate that the extract of S dulcis possess analgesic effects probably related to its antiinflammatory activity, effects probably attributable to the presence of glutinol and flavonoids.

Availability
Wild-crafted. 
Powders, extracts in the cybermarket.

Last Update December 2010

IMAGE SOURCE: Public Domain image / File:Scoparia dulcis Blanco1.19-original.png / Flora de Filipinas / 1880 - 1883 / Francisco Manuel Blanco (O.S.A) / Modifications by G. Stuart / Wikimedia Commons

Additional Sources and Suggested Readings
(1)
Weeds of Rain Fed Lowland Rice Fields of Laos & Cambodia / Monica L. Naples & Paul J. A. Kessler
Unpublished MSc thesis, University of Leiden ’.
(2)
Database File: Vassourinha (Scoparia dulcis)/ Raintree
(3)
Free Radical Scavenging Activity of Scoparia dulcis Extract / M Babincova and P Sourivong / Journal of Medicinal Food. September 2001, 4(3): 179-181. doi:10.1089/109662001753165765.
(4)
Effect of an aqueous extract of Scoparia dulcis on blood glucose, plasma insulin and some polyol pathway enzymes in experimental rat diabetes / M Latha and L Pari / Braz J Med Biol Res, April 2004, Volume 37(4) 577-586 / doi: 10.1590/S0100-879X2004000400015
(5)

Protective role of Scoparia dulcis plant extract on brain antioxidant status and lipidperoxidation in STZ diabetic male Wistar rats / Leelavinothan Pari et al / BMC Complement Altern Med. 2004; 4: 16.
/ doi: 10.1186/1472-6882-4-16.
(6)

Phytochemical and antimicrobial study of an antidiabetic plant: Scoparia dulcis L. / Latha M et al / Journal of medicinal food 2006;9(3):391-4.
(7)
Antitumor-promoting activity of scopadulcic acid B, isolated from the medicinal plant Scoparia dulcis L. / Nishino H et al / Oncology. 1993 Mar-Apr; 50(2): 100-3
(8)
Scoparic acid A, a beta-glucuronidase inhibitor from Scoparia dulcis / Hayashi T et al / J Nat Prod. 1992 Dec;55(12):1748-55.

(9)
Acetylated Flavonoid Glycosides Potentiating NGF Action from Scoparia dulcis / J. Nat. Prod., 2004, 67 (4), pp 725–727 / DOI: 10.1021/np0302908
(10)

Insulin-secretagogue activity and cytoprotective role of the traditional antidiabetic plant Scoparia dulcis (Sweet Broomweed) / Latha M pari et al / Life Sci. 2004 Sep 3;75(16):2003-14.
(11)
Scoparia dulcis L. (Scrophulariaceae) / GLOBinMED
(12)
Protective role of Scoparia dulcis plant extract on brain antioxidant status and lipidperoxidation in STZ diabetic male Wistar rats / Leelavinothan Pari and Muniappan Latha / BMC Complement Altern Med. 2004; 4: 16. / Online 2004 / doi: 10.1186/1472-6882-4-16.

(13)
Hepatoprotective Evaluation of Scoparia dulcis L. / Atish Kumar Sahoo and V Madhavan / Journ of Complementary and Integrative Medicine, Vol. 6 (2009) / Issue 1 / Research Articles
(14)
Antihyperglycaemic Effect of Scoparia dulcis.: Effect on Key Metabolic Enzymes of Carbohydrate Metabolism in Streptozotocin-Induced Diabetes / L Pari and M Latha / Summary Pharmaceutical Biology, 2005, Vol. 42, No. 8, Pages 570-576
(15)
Sympathomimetic effects of Scoparia dulcis L. and catecholamines isolated from plant extracts. / Freire S M, Torres L M, Soucar C and Lapa A J / J-Pharm-Pharmacol. 1996 Jun; 48(6): 624-8
(16)
Inhibition of Mineralization of Urinary Stone Forming Minerals by Medicinal Plants / N A Mohamed Farook et al /
(17)
Analgesic and antiinflammatory properties of Scoparia dulcis L. Extracts and glutinol in rodents / Sonia Maria de Farias Freire et al / Phytotherapy Research, Volume 7 Issue 6, Pages 408 - 414


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