HOME      •      SEARCH      •      EMAIL    •     ABOUT


Family Apocynaceae
Kalatsutsing-puti
Plumeria obtusa L.
WHITE CALACHUCHE
Da ji hua

Scientific names Common names
Plumeria apiculata Urb. Kalachuching-puti (Tag.)
Plumeria bahamensis Urb. Kalatsutsing-puti (Tag.)
Plumeria barahonensis Urb. Singapore graveyard flower (Engl.)
Plumeria beatensis Urb. Singapore plumeria (Engl.)
Plumeria bicolor Seem. White calachuche (Engl.) 
Plumeria cayensis Urb. White frangipani (Engl.) 
Plumeria clusioides Griseb.  
Plumeria bahaconfusa Britton  
Plumeria cubensis Urb.  
Plumeria cuneifolia Helwig  
Plumeria dictyophylla Urb.  
Plumeria ekmanii Urb.  
Plumeria emarginata Griseb.  
Plumeria estrellensis Urb.  
Plumeria inaguensis Britton  
Plumeria krugii Urb.  
Plumeria marchii Urb.  
Plumeria montana Britton & P.Wilson  
Plumeria nipensis Britton  
Plumeria nivea Mill.  
Plumeria obtusa L.  
Plumeria ostenfeldii Urb.  
Plumeria parvifolia Donn  
Plumeria portoricensis Urb.  
Plumeria tenorei Gazparr.  
Plumeria venosa Britton  
Plumeria versicolor Denhnh.  
Plumeria obtusa L. is an accepted name The Plant List

Other vernacular names
AFRIKAAN: Mohlare wa maswi wa sukiri.
BENGALI: Kathgolop.
CHINESE: Dun ye ji dan hua.
HINDI: Gulchin, champa.
MANIPURI: Khagi-leihao.
MEXICAN: Zopilote.
SWEDISH: Glansfrangipani.
THAI: Lanthom.

Gen info
- Revised taxonomy: The genus Plumeria of the Apocynaceae family was revised to contain P. rubra, P. obtusa, and their hybrids. Plumeria acuminata, P. acutifolia, and P. lutea, previously species names, are now recognized as botanical forms of P. rubra. (16)
- Study reports on the key to 40 major plumeria cultivars grown in Hawai'i, which is based on the most prominent color in the petal: reds, pinks, yellows, white, and blends. (16)
- Etymology: The genus name is in honor of 17th-century French botanist and Catholic monk, Charles Plumier. The common name "Frangipani" derives from the 16th-century marquis of an Italian noble family who claimed to have invented a plumeria-scented perfume, although it was a synthetic perfume resembling the odor of fragrant flowers.(26)
- In some parts of South East Asia, the tree and flower are considered sacred. Balinese Hindus use the flowers as temple offerings. (26)
- The two Plumeria species in this compilation are Plumeria rubra (P. acuminata, P. acutifolia,   Kalachuchi) and P. obtusa (white kalachuchi, Kalatsutsing-puti). P. obtusa leaves are pointed and oval, up to 18 centimeters long, with tubular flowers. P. rubra produce fragrant flowers with five spreading petals, yellow to pink, with oval or lance-shaped leaves 20 to 30 centimeters long.
- The frangipani is the national tree of Laos, called dak lampa, and where it is regarded as a sacred tree. It is also the national flower of Nicaragua.

Botany
Plumeria obtusa is a shrub or small tree growing up to 5 meters tall. Branches are thick, succulent, widely spaced, and covered with knobby protuberances. Stems and leaves yield a milky sap. Leaves are dark green, leathery, obovate to oblong-obovate, up to 30 centimeters long, with conspicuous parallel secondary veins running from the mid-vein, and clustered near the tips of the branches. Flowers are white, five-lobed, with a yellow center, borne in clusters at the end of the branches.

Distribution
- Widely cultivated in the Philippines.
- Native to tropical America.

Constituents
- Neutral N2 fraction of methanolic extract of fresh, undried and uncrushed leaves of Plumeria obtusa isolated a new lupane triterpenoids (1) along with five known compounds viz., obtusaline, betulinic acid, oleanolic acid, ursolic acid, kaneroside and oleandrin. (3)
- N3 neutral fraction yielded 10 new compounds (11-13, 15-19, 22, 23) together with 8 known compounds (7-10, 14, 20, 21, 24) isolated for the first time from this species, viz., a-amyrin (7) neriucoumaric acid (8), isonericoumaric acid (9), alphitolic acid (10), obtuscin (11), oytusinin (12), obtusilin (13), 3b.23-dihydroxyurs 12-en.28 oic acid (14), obtusidin (15-19), 27.p-Z.coumaroytoxyursolic acid (20), 27.p--E.coumaroytoxyursolic acid (21), coumarobtusanoic acid (22) coumarobtusane (23) and oleanonic acid (24). (3)
- Study of flowers for essential oil yielded 21 compounds viz.,
linalool, (Z)-geraniol, (Z)-citral, (E)-geraniol, (E)-citral, (Z)-beta-farnesene, (E)-beta-farnesene, 1-hexadecene, 2-methylpentadecane, alpha-farnesene, (Z)-farnesol, (E)-farnesol, (E)-farnesal , benzyl benzoate, 1-octadecanol, benzyl salicylate, eicosane, unknown1, unknown2, (E)-farnesyl acetate, and heneicosane. (see study below) (4)
- Phytochemical screening of various extracts of leaves yielded sterols, alkaloids, favonoids, terpenoids, glycosides, with absence of saponins. (see study below) (7)
- Study of fresh leaves yielded two new iridoids viz., 6″-O-acetylplumieride p-E-coumarate and 6″-O-acetylplumieride p-Z-coumarate, and three known iridoids viz., plumieride, plumieride p-Z-coumarate and plumieride p-E-coumarate.
(8)
- Oil of Plumeria obtusa was found rich in benzyl salicylate (45.4%) and benzyl benzoate (17.2%), with only minute concentrations of alkanoic acids. (12)
- Phytochemical screening of stem bark extract yielded triterpenoids, flavonoids, carbohydrate, essential oil, glycosides and alkaloids. (see study below) (13)
- Ethanolic extract of bark yielded alkaloids, flavonoids, tannins, and terpenoids. (see study below)
(14)

Properties
- Considered purgative, vulnerary, pectoral, hemostatic.
- Studies have shown antimicrobial, antiproliferative, antioxidant, insecticidal properties.

Parts utilized
Flowers, bark, leaves.

Uses
Edibility
· Caution / Toxicity: While some blogs have reported Plumeria flowers to be edible (eaten raw in salads or steep in tea), many advise against ingestion. All parts are considered toxic. The sap can cause a rash in sensitive people. The alkaloid content makes the plant extremely bitter, Ingestion may cause stomach pains and cramping. (19)Folkloric
· No reported folkloric medicinal use in the Philippines.
· Used for blenorrhagia, boils, herpetic lesions, sores, syphilis, and wounds. Used as cicatrizant, pectoral, purgative and hemostatic.
- Used in the treatment of diabetes, asthma, gonorrhea, and constipation; also, as contraceptive, expectorant, and anthelmintic. (
7)
· In Cambodia, bark decoction used as purgative; also used as remedy for edema.
· In the Sekhukhune District of
South Africa, decoction of leaves taken three times daily for diabetes. (9)
· In
Asia, decoction of leaves used for treating wounds and skin diseases. Bark and latex used as diuretic and purgative. (10)
Others
· Ornamental / Ritual: In Cambodia, flowers are used to make necklaces
; used in ritual offerings. In some Pacific Islands, such as Tahiti, Fiji, Hawaii, Samoa, New Zealand, plumeria flowers used for making leis.
· Oils / Perfumery: Essential oil used as ingredient in cosmetics, candles, potpourri, massage oils, and aromatherapy.
· Social indicator:
In modern Polynesian culture, women use the frangipani as social indicator: over the right ear signals seeking of a relationship, and over the left if taken. (
18)

Studies
Essential Oil / Flowers:
In various scented compound extraction methods using P. obtusa flowers, the major chemical component in the essential oils from all distillation methods and solvents was benzyl salicylate. Extracts from cold and hot enfleurage were linalool and n-undecanoic acid, respectively. Isolation of frangipani absolute by hexane extraction was considered the most appropriate method at pilot scale for extract use in perfume and cosmetic materials. (see constituents above) (4)
Antimicrobial / Flowers: Study evaluated various solvent extracts from flowers of P. obtusa for antimicrobial activity against a broad spectrum of human pathogenic organisms. The extracts showed variable degrees of inhibition of all microorganisms. Among gram positive bacteria, the most susceptible was B. subtilis, the most resistant S. aureus. Among gram negative bacteria, the most susceptible was Eriwina carotovora, the most resistant P. aeruginosa. (5)
Antimicrobial / Leaves:
Study evaluated various solvent extracts of leaves of P. obtusa for antimicrobial activity. Results showed PE, iso-butanol and EA fractions showed inhibitory activities against all nine microbial species except K. pneumonia and P. aeruginosa. (6)
Antioxidant / Leaves:
Study evaluated the phytochemical constituents and antioxidant potential of a methanol extract and fractions of P. obtusa leaves. Results showed moderate dose-dependent antioxidant activity based on DPPH and lipid peroxidation inhibition assays. (see constituents above) (7)
Antiproliferative / Leaves:
Study evaluated leaf extracts of 10 Apocynaceae species against three human cancer cell lines (MCF-7, MDA-MB-231, and HeLa). Plumeria obtusa was one of six plants that showed positive growth inhibitory activity, with ≤50% cell growth. The n-hexane extract of P. obtusa inhibited MCF-7 and HeLa cells. (10)
Insecticidal / Leaves:
Study evaluated the insecticidal efficacy of two Plumeria species (P. rubra and P. obtusa) foliar extracts on mosquito and beans weevil populations. P. obtusa yielded mosquito mortality rate of 86.2% and weevil mortality of 90%. while P. rubra was 88.75% and 95%, respectively. Results suggest potential applications in public health pest and disease management, food preservation and crop protection. (11)
Antiulcer / Stem Bark:
Study showed gastroprotective effects of P. obtusa stem bark extracts in peptic ulcer induced by pylorus ligation and indomethacin. The ulcer healing effects could be due to reduction in gastric acid secretion, gastric cytoprotection and proton pump inhibition. (See constituents above) (1
3)
Wound Healing / Leaves:
Study evaluated the wound healing activity of an ethanolic extract of Plumeria obtusa leaves in 2.5% , 5%, and 10% (F1, F2, F3, respectively) spray formulations in in-vivo wound healing models in white Wistar albino rats. In excision wound model, F3 showed complete wound healing on day 17, while F1 and F2 showed complete healing on day 21 and 19, respectively. In incision wound model, the F3 spray exhibited high tensile strength. Results showed F3 extract spray showed better and efficient wound healing activity compared to F1 and F2. (1
4)
Anti-Inflammatory / Bark:Study evaluated the anti-inflammatory effects of ethanolic extract of bark of Plumeria obtusa using animal models of cotton pellet method and carrageenan induced paw edema in male Wistar rats. Results showed highly significant (p<0.001) dose-dependent anti-inflammatory activity in both models. (see constituents above). (1
5)
Ursolic and Oleanic Acids Mixture / Antioxidant / Anticarcinogenic Potential to Melanoma Cells: Study evaluated the antioxidant and anticarcinogenic potential of oleanolic acid (OA) and Ursolic acid (UA) on B16 murine melanoma cell line isolated from P. obtusa, free and loaded in a nanoemulsion (NEm) system. The OA/UA natural mixtures exhibited high % of inhibition of DPPH with or without irradiation. The natural mixture incorporated into the NEm showed cytotoxic activity from 2.9 µM, whereas the free compounds from 17.4 µg. Results conclude the pentacyclic triterpene loaded in a NEm system has potential as new tool for further investigation as anticancer agent. (1
7)

Availability
- Ornamental cultivation. 
- Frangipani essential oil int he cybermarket.

Updated August 2020
October 2016


                                                    PHOTOS / ILLUSTRATIONS
Photos ©Godofredo Stuart / StuartXchange
OTHER IMAGE SOURCE: Flower Close up / File:Plumeria Acuminata.jpg / Venkatx5 / September 2012 / Creative Commons Attribution / Wikpedia / Click on image to see source image

Additional Sources and Suggested Readings
(1)
Plumeria obtusa / Synonyms / The Plant List
(2)
White Frangipiani / Common names / Flowers of India
(3)
STUDIES IN THE CHEMICAL CONSTITUENTS OF PLUMERIA OBTUSA AND STRUCTURE AND ACTIVITY RELATIONSHIP STUDIES IN THE HARMINE SERIES OF ALKALOIDS / Akhtar Naeed / Thesis / Pakistan Research Repository (Work embodied in this thesis has resulted in ten research papers)
(4)
Comparative Study of Scented Compound Extraction from Plumeria obtusa L.
/ Potechaman Pitpiangchan, Uraiwan Dilokkunanant, Udomlak Sukkatta, Srunya Vajrodaya, Vichai Haruethaitanasan, Putthita Punjee and Prapasson Rukthaworn* / Kasetsart J. (Nat. Sci.) 43 : 189 - 196 (2009)
(5)
Antibacterial and antifungal activity of solvent extracts from Plumeria obtusa Linn. / Ali N, Junaid M, Ahmad D, urRahman M, Ali N, Katzenmeier G / Trop Biomed. 2014 Dec;31(4):607-15.
(6)
Antimicrobial activity of leaves extracted samples from medicinally important Plumeria obtusa / Nasir Ali, Dawood Ahmad, Jehan Bakht*, Shahen Shah, Farman Ullah and Mueed-U-Rehman / Journal of Medicinal Plants Research, Vol. 7(17), pp 1121-1128, 3 May, 2013 / DOI 10.5897/JMPR12.223
(7)
Phytochemical analysis and In vitro antioxidant studies of Plumeria obtusa L. Leaves / Nittya k. Dogra / Indian J Pharm Sci, Jan-Feb 2016; 78(1): pp 169‑171 / DOI: 10.4103/0250-474X.180256 / PMCID: PMC4852569 / PMID: 27168698
(8)
Minor iridoids from the leaves of Plumeria obtusa / Bina Shaheen Siddiqui, Akhtar Naeed, Sabira Begum, Salimuzzaman Siddiqui / Phytochemistry, Volume 37, Issue 3, 14 November 1994, Pages 769-771 / doi:10.1016/S0031-9422(00)90355-8
(9)
Medicinal utilization of exotic plants by Bapedi traditional healers to treat human ailments in Limpopo province, South Africa / Sebua Semenya, Martin Potgieter, Milingoni Tshisikhawe, Soul Shava, Alfred Maroyi / Journal of Ethnopharmcology 144 (2012) 646-655
(10)
Antiproliferative and phytochemical analyses of leaf extracts of ten Apocynaceae species
/ Siu Kuin Wong, Yau Yan Lim, Noor Rain Abdullah, and Fariza Juliana Nordin / Pharmacognosy Res. 2011 Apr-Jun; 3(2): 100–106. / doi: 10.4103/0974-8490.81957
(11)
Insecticidal Efficacy of Plumeria Species Leaf Extract on Two Economically Important Insects Populations: Mosquito (Anopheles) and Bean Weevils (Callosobruchus Maculatus) / Aguoru, C. U.*, O a, K.L. and Olasan, J. O. / Journal of Herbal Medicine Research (JHMR), (2016), Vol. 1, Issue 02
(12)
AN REVIEW OF PHYTOCHEMICAL CONSTITUENTS & PHARMACOLOGICAL ACTIVITY OF PLUMERIA SPECIES / DEVPRAKASH, ROHAN TEMBARE, SUHAS GURAV, SENTHIL KUMAR G.P, T. TAMIZH MANI / Int J Curr Pharm Res, 2012; Vol 4, Issue 1: pp 1-6
(13)
Effects of Plumeria obtusa Linn. in Peptic Ulcer Induced by Pylorus Ligation and Indomethacin / Amit Pratap Singh, Vaibhav Shukla, Piuesh Khare / Journal of Pharmaceutical and Scientific Innovation, March-April 2012; 1(2): pp 26-32
(14)
Evaluation of in vivo wound healing activity of Plumeria obtusa L. (Champa) spray in rats / Tanay Bihani, Nilesh Mhaske et al / Wound Medicine, March 2020; Vol 28 / https://doi.org/10.1016/j.wndm.2019.100176
(15)
Anti-inflammatory Activity of an Ornamental Plant Plumeria Obtusa / Amogh R. Lotankar, Altamash J. Momin, Shaijesh Wankhede, Jyoti B. Sharma / Advances in Pharmacology and Pharmacy, 2016; 4(3): pp 23-26 / DOI: 10.13189/app.2016.040301
(16)
Plumeria in Hawai'i / Revision of taxonomy / Richard A Criley: College of Tropical Agriculture and Human Resources
(17)
Nanoemulsion Strategy for Ursolic and Oleanic Acids Isolates from Plumeria Obtusa Improves Antioxidant and Cytotoxic Activity in Melanoma Cells / Helen L Alvarado, Ana C Calpena, Maria L Garduño-Ramirez, Beatriz Clares et al / Anti-Cancer Agents in Medicinal Chemistry, 2018; 18(6) / DOI: 10.2174/1871520618666180111151846
(18)
About Frangipanis / AllThingsFrangipani
(19)
Poisonous Plants: Plumeria rubra / USDA.gov

                                                                          DOI
It is not uncommon for links on studies/sources to change. Copying and pasting the information on the search window or using the DOI (if available) will often redirect to the new link page. (Citing and Using a (DOI) Digital Object Identifier)

                                                            List of Understudied Philippine Medicinal Plants

HOME      •      SEARCH      •      EMAIL    •     ABOUT