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Family Costaceae
Insulin plant
Chamaecostus cuspidatus (Nees. & Martin) C.D Specht & D.W. Stev.
SPIRAL FLAG

Scientific names Common names
Chamaecostus cuspidatus (Nees & Mart.) C.D.Specht & D.W.Stev. Fiery costus (Engl.)
Costus cuspidatus (Nees & Mart.) Maas Insulin plant (Engl.)
Costus igneus N.E.Br. Spiral flag (Engl.)
Globba cuspidata Nees & Mart.  
Costus igneus N.E.Br. is a synonym of Chamaecostus cuspidatuss (Nees & Mart.) C. Specht & D.W.Stev. The Plant List
Chamaecostus cuspidatus (Nees & Mart.) C.Specht & D.W.Stev. is an accepted name. The Plant List

Other vernacular names
BENGALI: Piasal.
HINDI: Baanda, Bija-sal, Peisar, Jarul, Keukand.
GUJARATI: Pakarmula.
KANNADA: Kemou honne.
MALAYALAM: Honne, Karintakara, Vengai, Venna-maram.
MARATHI: Honi, Pushkarmula.
ODISHA: Vengis.
SANSKRIT: Asana, Bandhukapushpa.
SIDDHA: Kostum.
TAMIL: Neyccarikamaram, Venkal-c-ciray, Kostam, Kostum.
URDU: Bijasar, Bam al akhwain.
OTHERS: Kostum (Siddha). Sumbul chi khat.

Gen info
- The family Costaceae consists of four genera and about 200 species. The genus Costs is the largest in the family, with about 150 species of mainly tropical distribution. (14)
- The plant is related to the gingers and was once part of the Noninteracting family. However, the Costs species and kin have been reclassified in its own family, Costaceae. (18)
- The use of leaves as a dietary supplement for the treatment of diabetes has earned the catchphrase "a leaf a day keeps diabetes away."   (30)

Botany
Costus igneus is a perennial, upright, spreading plant growing to a height of 2 feet, with the tallest stems falling and lying on the ground. Leaves are simple, alternate, entire, oblong, 4-8 inches long with parallel venation, spirally arranged around the stems. Large, fleshy, smooth, and dark green leaves have a light purple underside. Flowers are yellow to orange, 1.5 inches in diameter, on cone-like head at the tips of branches. Fruits are green colored, less than 0.5 inch.

Distribution
- Introduced.
- Native to South and Central America.
- Widely cultivated in India for medicinal use.
- Ornamental cultivation.

Constituents
- Leaves are rich in protein, iron, and antioxidant components such as ascorbic acid, α-tocopherol, ß-carotene, terpenoids, steroids, and flavonoids.
- Ethanol extract of leaves yielded tannins, phlobatannins, saponin, flavonoids, terpenoids, and cardiac glycosides. (9)

- Study for essential oil yielded the following major constituents in %: (Stem) hexadecanoic acid (28.3), 9,12-octadecadienoic acid (18.33), dodecanoic acid (5.62), linalyl propanoate (6.03), tetradecanoic acid (4.82), α-eudesmol (3.55), γ-eudesmost (3.21) 4-ethoxy phenol (3.06); (Leaf) hexadecanoic acid (24.51), 2.pentanol (22.41), dodecanoic acid (3.96), ß-ionone (8.69), farnesyl acetone (7.04), α-ionone (8.01; (Rhizome) hexadecanoic acid (25.26), 9,12-octadecadienoic acid (7.74), dodecanoic acid (16.56), tetradecanoic acid (10.20), linalool (8.48), α-terpinol (4.44). (14)
- Proximate analysis yielded 15.3% protein,  120mg iron,  216mg ascorbic acid, 1833 µg ß-carotene,  25 mg α-tocopherol, 400 mmol GSH,  2.1g total phenols, and  1.89 mg/g extract of total flavonoids. (29)
- Phytochemical screening showed the presence of steroids, triterpenoids, alkaloids, tannins, glycosides, saponins, carbohydrates, and proteins. A methanol extract the highest content of phytochemicals. (30)
- Sequential screening  of leaves for phytochemical showed it is rich in protein, protein, iron, and antioxidant components such as ascorbic acid, α-tocopherol, ß-carotene, terpenoids, steroids, and flavonoids. (30)
- Qualitative analysis of a leaf extract yielded alkaloids, carbohydrates, saponin, protein, phytosterols, phenolic compounds, flavonoids, and glycosides. Quantitative estimation showed the leaves to have higher content of saponin and total flavonoids, with lesser amounts of phenols and alkaloids. (34)
-  Study reports on the  isolation, characterization and quantification of diosgenin from sapogenin extract of Costus igneus rhizome. Diosgenin present in the sapogenin extract was estimated at 0.5%.  (36)
- Ethanolic extract of leaves yielded carbohydrates, triterpenoids, alkaloids, proteins, tannins, saponins, flavonoids, and steroids. (see study below)   (37)
- Nutrient composition of dehydrated sample yielded 4.0% moisture, 2.8% fat, 6.3% total ash, 18% protein, 40mg iron,  6.6 mg phosphorus, 5.1mg calcium, 4.5g/100g total phenols, 0.848mg/g total flavonoids,  667µg ß-carotene, 149mg α-tocopherol, 81mg ascorbic acid,  75 m mols glutathione (GSH). (46)
- Proximate analysis of C. igneus cookies (% dry weight): Moisture 7.94%, solids 92.06%, total ash 70.7%, fat 3.75%, fiber 8.03%, protein 3.24%, total carbohydrate content 80.2%. Ascorbic acid was 4.2µg/g, ß-carotene 1.49µ/g and total phenolic content was 5.44mg/g.  Cookie antioxidant activity using DPPH radical scavenging assay showed 62.3%. (see study below) (45)

Properties
- Studies have suggest antimicrobial, antidiabetic, antiproliferative,antioxidant, anti-inflammatory, hepatoprotective properties.

Parts used
Leaves, roots, stem.

Uses

Edibility
- Flowers are edible, sweet.
Folkloric
- In the Philippines, becoming increasingly popular as an antidiabetic herbal medicine.
- In Siddha medicine, used for diabetes; leaves chewed twice daily, or dried powder of leaves taken 1/2 to 1 gram twice daily.

- Used by tribal people of Kolli hills of Tamilnadu for diabetes. (14)
- Leaves consumed as fresh, dried and powder leaf forms.
- In Mizoram, India, decoction of leaves and roots used to reduce blood sugar. (22)
- In west Sikkim, India, leave s used for treatment of diabetes, skin diseases, asthma, bronchitis, fever, and intestinal worm disease. (26)
- In Mexico, infusion of aerial parts used for treatment of renal disorders. (14)

Studies
Anti-Hyperglycemic / Dexamethasone Induced Hyperglycemia / Leaves:
Study evaluated the effect of Costus igneus leaves on dexamethasone-induced hyperglycemia in male Wistar rats showed reduction in fasting and postprandial blood sugar levels. 250 mg and 500 mg/kg/day of powdered leaves was comparable to Glibenclamide 500. (3)
• Antidiabetic / Acute Oral Toxicity Study / Leaves: Study evaluated the antidiabetic activity of C. igneus in alloxan induced diabetic albino rats. The ethanolic extract showed significant (p<0.001) antidiabetic activity. (4)
• Effect of Prediabetes and Diabetes in Neonatal STZ Rats: Study evaluated the effect of pre-treatment and post-treatment with isolated fraction of C. igneus on prediabetes and diabetes in neonatal streptozotocin induced T2DM. Treatment with CIF is beneficial in diabetic rats and can reduce the changes of progression of pre-diabetes into T2DM. Effect may be due to increase in peripheral utilization of glucose and insulin mimetic effect. (5)
• Acute Oral Toxicity Study: Acute oral toxicity studies of CIF fraction of chloroform extract showed no abnormal or toxic symptoms in mice treated with 5, 50, 500, 2000 mg/kg. LD 50 value is above 2 g/kg.  (5)
• Anti-Proliferative / Apoptotic / Leaves: Study evaluated the anti-proliferative and apoptotic potential of ME of Costus igneus on in vitro MCF-7 Breast cancer cell line. Results showed reduction of tumor size without affecting the normal cells. (6)
• Antidiabetic / Hypolipidemic / Rhizomes: Study evaluated the antihyperglycemic and hypolipidemic activities of methanol extract of rhizomes in STZ induced diabetic albino rats. Results showed significant (p<0.05) decrease in FBS, TC, TG, LDL, and VLDL levels, with significant (p<0.05) increase in HDL levels. (7)
• Antimicrobial / Rhizome: Study evaluated the rhizome extract of three Costus species (C. speciosus, C. pictus, and C. igneus) for antimicrobial activity. The rhizome extract of the three species inhibited the growth of all the test fungi. The C. igneus extract showed higher activity against S. aureus, followed by P. aeruginosa, E. coli, and B subtilis. (8)
• Amylase Inhibitory Activity / Leaves: Study evaluated the amylase inhibitory activity of methanol leaf extract of C. igneus by Chromogenic DNSA assay. The extract showed dose dependent α-amylase inhibition of 65.48, 35.72, and 3.57% at 500, 250, and 100 µg concentration. (10)
• Silver Nanoparticles / Antidiabetic: Study reports on the simple and cost-effective synthesis of silver nanoparticles using C. igneus extract. The C. igneus mediated nanoparticles showed high antidiabetic activity and maximum amylase inhibition concentration of 87% at 100 µg. The AgNPs showed good antidiabetic activity than the plant extracts. (11)
• Hepatoprotective / Paracetamol Induced Liver Damage: Study evaluated the hepatoprotective activity of C. igneus in paracetamol induced hepatic damage. Administration of C. igneus extract prior to acetaminophen effectively (p<0.05) prevented the induction of damage by acetaminophen. The 400 mg/kg dose of C. igneus was comparable to the standard drug silymarin. (12)
• Potential Anticancer Source: Study evaluated the cytotoxicity activities of crude ethanolic extracts from Chaemaecostus subsessilis and C. cuspidatus and six fractions against a panel of six human cancer cell lineages (HL60, Jurkat, MDA-MB231, MCF-7, HCT, THP-1). Cytotoxic effects in the HL60, Jurkat and THP-1 lineages were mediated via an apoptotic mechanism. (13)
• Antidiabetic / Antioxidant / Antimicrobial / Leaves: Study of an aqueous leaf extract of C. cuspidatus showed antidiabetic against streptozotocin induced diabetic mice. Antioxidant activity was evaluated using DPPH, superoxide anion scavenging activity, hydroxyl radical scavenging activity and reducing power assays. Antibacterial activity was tested against S. aureus, B. subtilis, E. coli and antifungal activity against A. flavus and C. albicans. (16)
• Gold Nanoparticles / Antidiabetic / Leaves: Study reports on the green synthesis of gold nanoparticles using insulin plant Chamaecostus cuspidatus leaf powder extract. The gold nanoparticles exhibited 50% inhibition of free radicals. Treatment of diabetic mice with the gold nanoparticles restored blood glucose, glycogen, and insulin level. (17)
• Toxicity Studies: Acute oral toxicity studies of aqueous extract of C. pictus at various doses from 5, 10, 20, and 40 g/kg body weight. None of the extract doses produced mortality or any behavioral disorders. Administration of 1 g/kbw per day for 30 days, likewise, produced no mortality or behavioral effects. An ethanolic extract of leaves from 50 mg/kbw up to 5000 mg/kbw showed no mortality or significant toxicity. (15)
• Antihyperglycemic / Insulin Plant Leaves and Curcuma longa Rhizome: Study evaluated the antihyperglycemic activity of insulin plant leaves and unprocessed rhizome of Haridra (Curcuma longa) in rabbits with diabetes induced by dexamethasone, Results showed extremely significant(p=0.0001 decrease in blood glucose levels in both groups. Unprocessed haridra showed significant )p=0.0109) decrease in blood glucose level as compared to insulin plant leaves. (18)
• Antifungal / Saponins / Rhizomes: Study evaluated the antifungal activity of crude ethanol extracts of leaves, stems, and rhizomes of Chamaecostus cuspidatus against Candida and Trichophyton species. Only the rhizomes showed antifungal activity and had no activity against bacteria (S. aureus and E. coli). The hexane fraction from the rhizome extract showed the best antifungal effect. Three known saponins were isolated from the fraction, of which two (dioscin and aferoside A) showed good antifungal activity. Fungicidal activity caused significant changes in the morphology of the fungal cells and showed anti-Candida albicans biofilm activity. (20)
• Hypoglycemic Action of Insulin-Like Protein / Toxicity Study: An earlier study reported an orally active insulin-like protein from Costus igneus with potent hypoglycemic effect in STZ-induced diabetic Swiss mice. This study elucidated the hypoglycemic mechanism of the ILP. Results showed the orally active ILP acts via an insulin signaling pathway. The ILP did not show toxicity in normal and diabetic Swiss mice. (21)
• Antimicrobial / Steroid / Stem: Study of ethanol extract of Costus igneus stem isolated a steroid compound. The compound was tested for antimicrobial activity against S. aureus, E. coli, and C. albicans. Results showed good antibacterial and antifungal activity. (23)
• Comparative Hypoglycemic and Hypolipidemic Activity: Study compared the therapeutic effects of C. igneus methanolic and aqueous extracts against hyperglycemia and hyperlipidemia in alloxan induced diabetic rats. The methanol extract exhibited higher activity than the aqueous extract. (24)
• Silver Nanoparticles / Antimicrobial / Leaves: Study reports on the synthesis of antibacterial nanoparticles using a leaf broth of Costus igneus. The silver nanoparticles showed enhanced antibacterial activity against well known pathogenic strains viz. Streptococcus sp., Pseudomonas aeruginosa, Staphylococcus sp., Proteus sp., as well as fungi Penicillium sp., Mucor sp., Candida albicans, Aspergillus sp. (25)
• Chlorogenic Acid Mediated Silver Nanoparticles / Free Radical Scavenging / Anti-Inflammatory: Study evaluated the antioxidant and anti-inflammatory properties of chlorogenic acid medicated silver nanoparticles. Results showed significant anti-inflammatory and anti-oxidation activity of chlorogenic mediated AgNPs. which proportionately increased with increasing concentration. (27)
• Hypoglycemic Carbon Dots: Study evaluated the hypoglycemic bioactivity of novel eco-friendly carbon dots derived from Costus igneus. The carbon dots were synthesized from by a simple hydrothermal treatment at relatively low temperature. The carbon dots inhibited alpha-amylase in a concentration dependent manner, suggesting C. igneus has antidiabetic property. (28)
• Effect of leaves on Blood Glucose Levels of Diabetic Patients: A Cross-Sectional Study: A cross0awxtional study in diabetic patients evaluated the effect of consumption of insulin plant on  glycemic control. Retrospective data was  was collected from diabetic patients who consumed the leaves of the insulin plant. in fasting and postprandial blood sugar levels in all the patients who consume the leaves. (31)
• Anti-Urolithic /  Calcium / Leaves: Study evaluated a methanolic extract of leaves of Costus igneus   for in-vitro anti-urolithic activity. The  percentage  dissolution of calcium oxalate in the presence of the extract in semi-permeable egg membrane was studied and compared with standard drug cystone. Percentage dissolution was 86.12% for the extract and  79.34% for cystone.  Results suggest potential for use in treatment of urolithiasis and can be added to polyherbal formulations. (32)
• Antioxidant / Cytotoxic / Anticancer / Leaves: Study evaluated the antioxidant and cytotoxic potential of different leaf extracts A hexane extract showed highest Antioxidant activity was evaluated using FRAP, ABTS, . DPPH and reducing power assay while cytotoxicity was evaluated using  MTT assay on breast cancer cell line MCF-7 (Michigan  Cancer Foundation). In FRAP assay, the acetone extract showed highest antioxidant activity, the hexane extract in ABTS showed highest radical scavenging activity, and the acetone extract in DPPH assay. The acetone  leaf extract  at concentration of 150µg/ml showed highest cytotoxic activity on the cancer cell line with cell viability of 65.51%. Results suggest efficient antioxidant and cytotoxic activity and could be a safe and cost-effective  potential for biologic applications. (33)
• Antiangiogenic / Non-Teratogenic / Leaves: Study evaluated the anti-angiogenic potential of crude ethanolic extract of Costus igneus through chorioallantoic membrane (CAM) vascularity and teratogenicity assays in  mallard duck (Anas platyrhynchos). Teratogenicity assay showed statistically insignificant gross  morphological abnormalities. The extracted crude crude ethanolic substance did not contain components that can significantly inhibit angiogenesis. Also, results reveal insulin plant has no teratogenic effect. (34)
• Insulin-Like Protein (ILP): Insulin-like protein (ILP) is purified from Costus igneus. The ILP showed cross-reactivity  with murine anti-insulin antibodies, hence was purified by affinity chromatography using anti-insulin antibodies.. The ILP was structurally different but functionally similar to insulin. The  ILP significantly decreased blood glucose in OGTT given orally to normal and diabetic mice.  The ILP is a novel protein with oral hypoglycemic activity. (35)
• Cytotoxicity / Hepatocellular Carcinoma / Leaves: Study evaluated   the in vitro anticancer activity of ethanolic extract of Costus igneus leaves against hepatocellular carcinoma (HepG2) cells. %h4 concentration required for 50% viability *IC50) was calculated at  62.5µg/mL.  Results showed cytotoxic activity against liver cancer cells. (see constituents above)  (37)
• ZnO Nanoparticles / Antibacterial / Leaves: Study reports on the synthesis of high-purity zinc oxide nanoparticles from Costus igneus leaves using different solvents.  The hot water extract-based green synthesis process yielded higher purity (99.89%) and smaller particle size  (94nm) than other solvents.  The NPs showed antibacterial activity against Gram-positive S. aureus and S.epidermis and Gram-negative E. coli and K. pneumoniae. Results suggest the green-synthesized high-purity NPs has potential for therapeutic and cosmetic applications.  (38)
• Salicylic Acid as Plant Elicitor to Increase Productivity: New approaches are being developed to protect the plant source and to enhance productivity in terms of phytochemicals to  balance supply and demand. Flavonoid diglycosides and sapogenins are mostly responsible for the anti-diabetic activity. Due to over exploration, alternative methods are developed to protect the plant in their natural habitat. Elicitors are compounds that stimulate plant defense pathways. Release of secondary metabolites are triggered by elicitors. This study evaluated the application of Salicylic acid (SA) in different concentrations as elicitor. Results showed SA enhances the quantity of desired phytopharmaceuticals, which play an essential role in plant defensive pathways. (39)
• Flavonoids / Hypoglycemic Impact / Rhizome: Study isolated and quantified flavonoids from ethanol extract of Costus igneus rhizome and the impact of CiREE on hypoglycemic effect in STZ-induced diabetic rats. Quercetin  (Rf-0.72. 0.794%) and kaempferol (Rf-0.35, 4.2%) were quantified by HPTLC. Results showed that treatment with CiREE pf rats with pretreatment abnormalities ( increased elevated blood glucose, serum TC,  TG, LDL, VLDL and decreased HDL, glycogen and insulin levels) resulted in reversal back to normal. Histopathological and electron microscopy  study of the pancreas showed increase in number of ß-cells and insulin granules. Results showed the CiREE has potent antidiabetic effect comparable to that of standard reference drug glibenclamide. (40)
• Antidiabetic / Toxicity Study / Leaves: Study evaluated acute toxicity and antidiabetic effect of C. igneus extracts (acetone, hexane, hot water) on STZ-induced diabetic wistar albino rats. Acute toxicity testing  showed various tested extracts did not show any mortality at all tested concentrations. The hexane extract of leaves caused significant (p<0.001) reduction of blood sugar level. There was also significant reduction in  BUN. Significant reduction of creatinine was observed at 400mg/kg in all three leaf extracts. Results were equipotent to glibenclamide. Results suggest a safe and cost-effective herbal drug for the treatment of diabetes.  (41)
• Anti-Urolithic /  Calcium Oxalate / Stems: Study evaluated the effects of aqueous and ethanolic extracts of C. igneus stem on calcium oxalate urolithiasis in male albino wistar rats. Results concluded that treatment with aqueous and ethanolic extract had an inhibitory effect on calcium oxalate urolithiasis. Lupeol and stigmasterol were confirmed by HPTLC technique.  (42
• Anti-Diabetic /  Increased Insulin and GLUT3  Expression / Leaves: Study  evaluated lost ß-cell regeneration in diabetes and successfully differentiated human haematopoietic stem cells (HSCs) from functional ß-like cells. Costus igneus  leaf extract is known to exhibit anti-diabetic properties by lowering blood glucose level in mice models. This study evaluated the effect of C. igneus on differentiated ß-like cells. The Ci leaf extract exhibited anti-diabetic property elevated  glucokinase activity which catalyzes the rate-limiting step of glucose catabolism in ß-like cells  and acts as a sensor for insulin production while decreasing  the  glucose-6-phosphatase activity. Results showed enhanced IBS and GLUT2 gene expression and elevated glucokinase activity in ß-like cells differentiated from HSCs. The extract has potential for use in the treatment of diabetes. (43)
• Antibacterial / Roots: Study evaluated acetone, chloroform, and methanol extracts of roots for antimicrobial activity against  four Gram-negative bacteria viz Pseudomonas aeruginosa, Klebsiella pneumonia,  Salmonella sp. and Proteus vulgaris.  K. pneumonia was found most susceptible to both growth regulators IBA and IAA derived roots, with  25 mm zone of clearance, which was almost equal to commercial antibiotic gentamicin. (44)
• Antidiabetic Insulin Plant Cookies / Leaves: Study reports on the formulation of a nutritionally rich cookie with Costus igneus leaf extract and evaluates the effect of cookie consumption on decreasing blood sugar levels in 30 type 2 diabetic patients. Proximate analysis showed the cookies contain high amounts of secondary metabolites including antioxidant compounds.  The cookies showed good
α-amylase inhibitory activity. Results showed significant reduction of blood glucose levels. There was a one unit drop in HbA1C.  Results showed good antidiabetic and antioxidant activities and potential as a therapeutic and functional food source for the treatment of obesity and diabetes. (see constituents above) (45)

Availability
- Cultivated.
- Increasing availability in herbal gardens.
- Powdered leaves, rhizomes, capsules and teas in the cybermarket.

© Godofredo U. Stuart Jr., M.D. / StuartXchange

Updated  Feb 2022 / Jan 2021 / Dec 2018 / Jul 2018 / Jan 2018
November 2017


PHOTOS / ILLUSTRATIONS
Photos © Godofredo Stuart / StuartXchange

Additional Sources and Suggested Readings
(1)
Kostum-Herbal Remedy for Diabetes / Siddham

(2)
Chamaecostus cuspidatus (Nees & Mart.) / Synonyms / The Plant List
(3)
Effect of the insulin plant (Costus igneus) leaves on dexamethasone-induced hyperglycemia / Akhila J Shetty, Divya Choudhury, Rejeesh, Vinod Nair, Maria Kuruvilla, and  Shashidhar Kotian / Int J Ayurveda Res. 2010 Apr-Jun; 1(2): 100–102. / doi:  10.4103/0974-7788.64396
(4)
Antidiabetic activity of insulin plant (Costus igneus) leaf extract in diabetic rats / Bhat Vishnu, Asuti Naveen,Kamat Akshay, Patil M B /
Journal of Pharmacy Research 2010, 3(3): pp 608-611 ISSN: 0974-6943
(5)
Effect of Costus igneus: The insulin plant, on prediabetes and diabetes in neonatal streptozotocin rats
/ Murthy EGK Talasila, Hemalatha Bavirisetti, Jithendra Chimakurthy, Mayuren Candasamy / Journal of Health Sciences, Vol 4, No 3 (2014) / DOI: https://doi.org/10.17532/jhsci.2014.163
(6)
In Vitro Anti-Proliferative Potential of Leaves of Costus Igneus / Prof. S. Dhanasekaran, M. Akshaya, S. Preethi / International Journal of Innovations in Engineering and Technology (IJIET), December 2014; Vol 4, Issue 4 / ISSN: 2319-1058
(7)
Efficacy of Methanolic Extract of Costus Igneus Rhizome on Hypoglycemic, Hypolipidimic Activity in Streptozotocin (STZ) Diabetic Rats and HPTLC Analysis of Its Active Constituents / Pazhanichamy Kalailingam, Rajendran and Eevera Tamilmani / 2011 International Conference on Bioscience, Biochemistry and Bioinformatics IPCBEE Vol 5 (2011)
(8)
Evaluation of antibacterial activity in three species of Costus / G.Sulakshana*, A. Sabitha Rani and B.Saidulu / Int. J. Curr. Microbiol. App. Sci (2013) 2(10): pp 26-30
(9)
Pharmacognostical and Phytochemical study of Costus igneus NE Br leaf / Meena S. Deogade , Anita Wanjari, Seema C. Lohakare / J-ISM, V2 (4), Oct-Dec 2014, pp 174-178
(10)
AMYLASE INHIBITORY ACTIVITY OF COSTUS IGNEUS LEAF EXTRACT / ND Satyanarayan *, Mohammedsiraj Mirji, Anantacharya and Sanjeevkumar Giri / International Research Journal of Pharmaceutical and Applied Sciences, Vol 5, Issue 1, 2015 / pp 12-15
(11)
Bio synthesis, characterization and activity studies of Ag nanoparticals, by (Costus ingneus) insulin plant extract / Sanjeevaraddi R Sataraddi, Sharanappa T Nandibewoor* / Der Pharmacia Lettre, 2012, 4 (1):152-158
(12)
Hepatoprotective activity of Costus igneus against Paracetamol induced liver damage / Nimmy Chacko* and CS Shastry / International Journal of Advances in Pharmacy, Biology and Chemistry, IJAPBC, Vol. 1(2), Apr- Jun 2012
(13)
Chamaecostus subsessilis and Chamaecostus cuspidatus (NNees & Mart)) C..SSpecht and D..WW..SStev as Potential Sources of Anticancer Agents / Ezequias Pessoa de Siqueira, Jonas Pereira Ramos, Carlos Leomar Zani, Albina Carvalho de Oliveira Nogueira, David Lee Nelson, Elaine Maria de Souza-Fagundes and Betania Barros Cota / Natural Products Chemistry & Research (2016), 4(2) / DOI: 10.4172//22329--66836.1000204
(14)
A review on Insulin plant (Costus igneus Nak) / Prakash K. Hegde, Harini A. Rao, and  Prasanna N. Rao / Pharmacogn Rev. 2014 Jan-Jun; 8(15): 67–72. /doi:  10.4103/0973-7847.125536
(15)
CHAMAECOSTUS CUSPIDATUS – A SHORT REVIEW ON ANTI DIABETIC PLANT / A. Naga Jyothi, E. Priyanka, D. Eswar Tony, Rama Rao Nadendla /  IAJPS 2015, 2 (7): pp 1110-1113
(16)
In Vivo Antidiabetic and In Vitro Antioxidant and Antimicrobial Activity of Aqueous Leaves Extract of Chamaecostus cuspidatus / Mohemedibrahim Ponnanikajamideen, Rajeshkumar Shanmugam, and Annadurai Gurusamy / Research Journal of Pharmacy and Technology 9(8), Aug 2016 / DOI: 10.5958/0974-360X.2016.00230
(17)
In-Vivo Anti-Diabetic and Wound Healing Effect of Antioxidant Gold Nanoparticles Synthesized Using Insulin Plant (Chamaecostus Cuspidatus) / M. Ponnanikajamideen, S Rajeshkumar, M Vanaja, G Annadurai / Canadian Journal of Diabetes / DOI: https://doi.org/10.1016/j.jcjd.2018.05.006
(18)
Anti-hyperglycemic activity of Insulin plant leaves (Chamaecostus cuspidatus Nees & Mart/ CD Specht & D W Ste) and unprocessed Harida rhizome (Curcuma longa L.) / Meena Shamrao Deogade, Niteen Ambatkar, Bhushan Ambatkar / Journal of Indian System of Medicine, 2017; 5(3): pp 203-207
(19)
Chamaecostus cuspidatus / Wikipedia
(20)
Antifungal activity of extracts and purified saponins from the rhizomes of Chamaecostus cuspidatus against Candida and Trichophyton species / B Barros Cota, D Batista Carneiro de Oliveira, T Carla Borges et al / Journal of Applied Microbiology, Jan 2021; 130(1): pp 61-75 / DOI: https://doi.org/10.1111/jam.14783
(21)
Elucidation of hypoglycemic action and toxicity studies of insulin-like protein from Costus igneus / Manasi R Hardikar, Mokshada E Varma, Anjali A Kulkarni, Prasad P Kulkarni, Bimba N Joshi / Phytochemistry, April 2016; Vol 124: pp 99-107 / DOI: https://doi.org/10.1016/j.phytochem.2016.02.001
(22)
Commonly used medicinal plants in N. Mualcheng, Mizoram, India / Lalbiakngheti, Lucy Lalawmpuii / Science Vsion, 31 Dec 2020, 20(4): pp 156161 / DOI: https://doi.org/10.33493/sci.vis.20.04.03
(23)
Isolation and biological evaluation of steroid from stem of Costus igneus / R Saraswathi, Upadhyay Lokesh, R Venkatakrishna, R Meera, P Devi / Journal of Chemical and Pharmaceutical Research, 2010; 2(5): pp 444-448 / ISSN: 0975-7384
(24)
Comparative evaluation of extracts of C. igneus (or . pictus) doe hypoglycemic and hypolipidemic activity in alloxan diabetic rats / Panagal Mani, R A Kumar, T M Bastin, S Jennifer, Muthuvel Arumugam / International Journal of Pharmacy and Technology, 2010; 2(1): pp 183-195 / ISSN: 0975-766X
(25)
Antimicrobial activity of silver nanoparticles synthesized by using Costus igneus / S Vasantharaj, S Sathiyavimal, N Hemashenpagam / Research Journal of Pharmaceutical, Biological, and Chemical Sciencrs, 2013; 4(2): pp 733-738 / ISSN: 0975-8585
(26)
Ethnobotanical survey of threatened medicinal plants of West Sikkim / Mahendra Tamang, Krishan Pal, Santosh KUmar Rai, Abul Kalam, S Rehan Ahmad / International Journal of Botany Studies, Sept 2017; 2(6): pp 116-125 / ISSN: 2455-541X
(27)
Free Radical Scavenging and Anti-Inflammatory Activity of Chlorogenic Acid Mediated Silver Nanoparticle / Anu Iswarya Jaisankar, Lakshminarayanan Arivarasu / Journal of Pharmaceutical Research International, 2020; 32(19) / DOI: https://doi.org/10.9734/jpri/2020/v32i1930715
(28)
Hypoglycemic bioactivity of novel eco-friendly carbon dots derived from traditional Costus igneus / A Niveditha, A Sankari, V Priya, V Vishnu. R Gayathri / Drug Invention Today, Sept 2019; 12(9): pp 2045-2047
(29)
Nutrient profile and antioxidant components of Costus speciosus Sm. and Costus igneus Nak. / D. Vishalakshi Devi, Asna Urooj /  IJNPR--Indian Journal of Natural Products and Resources, 2010; 1(1): pp 116-118  /  eISSN 0976-05 12 / pISSN0976-0504
(30)
A Review on Medicinal Exploration of Costus igneus: The Insulin Plant / Flowerlet Mathew, Bimi  Varghese / Int J Pharm Sci Rev Res., 2019;  54(2) Article 10: pp  51-57
(31)
Effect of insulin plant (Costus igneus) leaes on blood glucose levels in diabetic patients: A cross-sectional study / A J Shetty.  S M Parampalli,  R Bhandarkar, S Kotian / Journal of Clinical and Diagnostic Research,  4(3): pp 2617-2621
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In-Vitro Evaluation of Anti-Urolithic Activity of Leaves Extract of Costus igneus / D Kushagra, S Rajiv,  G Ruchi,  M Neelesh / Journal of Pharmacy and Technology, 2020; 13(3): pp 1289-1292 /
DOI: 10.5958/0974-360X.2020.00237.1
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Antioxidant and Cytotoxic Potential of Leaf Extracts of Costus igneus / Waseem Iqbal  Khanday, Nazir Ahmad  Wani,  Balaji Paulraj /  Journal of Natural Science, /biology and Medicine,  2019; 10(2): pp 157-166 / DOI:  10.4103/jnsbm.JNSBM_216_18
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Qualitative and quantitative phytochemical analysis of Costus igneus leaf extract / Dr C Muthukumar, Dr L Cathrine, S Gurupriya / Journal of Pharmacognosy and Phytochemistry, 2019; 8(4): pp 1595-1598
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Angiosuppressive and Teratogenic Influence of an Edible Medicinal Herb, Insulin Plant  (Costus igneys) in Mallard Duck (Anas platyrhynchos) Embryos / Abdul  Latiph L Yahya / Cebu International Conference on Viomedical, Medical, and Pharmaceutical Sciences, Jan 2017 /
DOI: http://doi.org/10.17758/URUAE.AE0117303
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Orally active hypoglycemmic protein from Costus igneus N.E.Br.: An in vitro and in vivo study /  Bimba N Joshi, Hitendra Munot, Manasi Hardikar, Anjali A Kulkarni / Biochemical and Biophysical Research Communnications,  2013; 436(2):  pp 278-282 / https://doi.org/10.1016/j.jbbrc.2013.05.093
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Isolation, Characterization and quantification of diosgenin from Costus igneus /  Kalailingam Pazhani et al /  Journnal of Planar Chromatography-Modern TLC, 25(6) / DOI: 10.1556/jpc.25.2012.6.13
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In Vitro Cytotoxicity Activity if Ethanolic Leaf Extract of Cistus igneus Against Hepatocellular Carcinoma (HepG2) Cells / Glory Josephine, K Punnagai / Biomed Pharmacol J; 2019; 12(2) /
DOI: https://dx,doi.org/ 10.13005/bpj/1715
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Influence of solvents on the changes in structure, purity, and in vitro characteristics of green-synthesized ZnO nanoparticles from Costus ignrud. / G Nandhini,   Oscar Komla Awitor,  R Suriyaprabha / Applied Nanoscience,  2018; 8: pp  1353-1360 / DOI: httpd://doi.org/s13204-018-0810-0/
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The effect of plant defence elicitor on Costus igneus for the enhanced phytochemical prod\uctivity / Rajiv Saxena, Kartik Chaudhary, Lrishna Agtawal et al / Journal of Drrug Delivery and Therapeutics, 2019; 9(3) / DOI: https://doi.org/10.22270/jddt.v9i3.2890
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Isolation and quantification of flavonoids from ethanol extract of Costus gneus rhizome (CiREE) and impact pf CiREE on hypoglycemic, electron microscopic studies of pancreas on streptozotocin (SRZ)-induced diabetic rats / Pazhanichamy Kalailingam, Kunthavai Balasubramanian.  Rajendran  Kaliaperumal et al /  Biomedicine & Preventive Nutrition, 2011; 3(3): pp  285-297 /  DOI: 10.1016/j.bionut.2013.01.001
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Antidiabetic Potential of Costus igneus Leaf in Streptozotocin Induced Biabetic Wistar Albino Rats / Waseem Iqbal Khanday. Nazir Ahmad Wani, Balaji Paulraj / Journal of Experimental Biology and Agricultural Sciences, 2019; 7(1): pp  65-73 /  ISSN: 2320-8694
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Effects of Costus igneus stem extract on calcium oxalate urolithiasis in albino rats / K. Manjula, K. Rajendran, S. Kumaran / Urological Research, 2012; Vol 40: pp 499-510 / https://doi.org/10.1007/s00240-012-0462-6
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Increased insulin and GLUT 2 gene expression and elevated glucokinase activity in ß-like cells of islets of langerhans differentiated from human haematopoietic stems cells on treatment with Costus igneus leaf extract /  Surekha Kattaru,  Venkata  Gurunadha Krishna Sarma Potukuchi et al / Molecular Biology Reports, 2021; Vol 48: pp  4477-4485 / DOI: https://doi.org/10.1007/s11033-031-06467-x
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Studies on Antibacterial Activity of Root Extract of Costus igneus / A Saravanan, S Karunakaran, P Vivek, S Dhanasekaran /   International Journal of ChemTech Research, 2014; 6(9): pp  4201-4206 /  ISSN: 0974-4290
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Evaluation of cookies formulated with Costus igneus Plant Material for Antidiabetic Activity / A Rajani Chowdary, Raaththika R, Payala Vijayalakshmi / Medico-Legal Update, 2020; 20(3)
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Nutrient profile and antioxidant components of Costus speciosus Sm. and Costus igneus Nak . / Vishalakshi Devi D and Asna Urooj / Indian Journal of Natural Products and Resources, 2010; Vol 1(1) pp 116-118 /   eISSN 0976-05 12 / pISSN0976-0504

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