Dapong-kahoi is a bushy parasitic shrub. Branchlets and leaves beneath are densely covered with a tomentum of long- and short-branched hairs. Leaves are opposite, and shortly petioled, usually roundish-elliptical, 5 to 10 centimeters long, 2 to 5 centimeters wide, and smooth above when old. Inflorescence is usually 2- to 5-flowered. Flowers are 1.2 to 2.5 centimeters long, in axillary, stalkless or short-peduncled fascicles. Calyx tube is obovate or pear-shaped, 2.5 to 3.5 millimeters long, with the limb entire. Corolla is slender, 7 to 17 millimeters long, with the tube split, and with 4 lobes. Fruit is clavate, 8 to 10 millimeters long, 3 to 4 millimeters thick, and hairy.
- A parasitic on miscellaneous trees in many islands, in open forests only a low altitudes in Palawan.
- Also occurs in the China, Cambodia, Indonesia, Laos, Malaysia, Burma, Thailand and Vietnam.
- Ethyl acetate fraction of Scurrula ferruginea yielded an unusual flavanol, glycoside 4"-O-acetyl-quercitrin, together with quercetin and quercitrin.
- Plant decoction used for malaria.
- Poultice of leaves used for wounds and snake bites.
- Decoction of leaves used as protective medicine after childbirth.
- In Malaysia, used as postpartum protective remedy; also to treat malaria, wounds and snakebites.
• Vascular Relaxation / Anti-Hypertensive: Study of n-butanol fraction of methanol extract of Loranthus ferrugineus showed it induced vascular relaxation by stimulating muscarinic receptors, activating the endothelium-derived nitric oxide-cGMP-relaxant pathway, promoting prostacyclin release. Results support its traditional use as anti-hypertensive agent. (1)
• Cholinomimetic Effect: Study of a methanol extract of L. ferrugineus in isolated guinea pig ileum showed a spasmogenic effect probably mediated through a direct action on intestinal muscarinic receptors. (2)
• Antihypertensive / Vasoconstriction Modulation: Study investigated the mode by which LF methanol extract antagonizes or modulates norepinephrine-induced vasoconstriction in rat aortic rings. Results showed LF ME exerted its vascular effect by reversible noncompetitive antagonism of norepinephrine-induced vasoconstriction, providing a mechanism for its antihypertensive effect. (3)
• Antiviral / Cytotoxic: Extracts of Scurrula ferruginea have been found to have antiviral activity against herpes simplex virus and poliovirus. Extracts were also cytotoxic against murine Lewis lung carcinoma, mouse lymphocytic leukemia (LI210), human erythromyeloblastoid leukemia (K562), human glioblastoma (U251), human prostatic carcinoma (DU145) and human breast adenocarcinoma (MCF-7) cells. (5)
• Flavonols / Cytotoxicity: Ethyl acetate fraction of Scurrula ferruginea yielded an unusual flavonol glycoside 4"-O-acetyl- quercitrin, together with quercetin and quercitrin. On cytotoxic evaluation on four human cancer lines, quercetin was the most active with an IC50 of 35 µm on U251 (human glioblastoma cells). (6)
• Vasorelaxant / Blood Pressure Lowering Activity: Study evaluated various extracts of aerial parts for blood pressure lowering activity in in vitro and in vivo animal models. Results showed the methanol extract to be most active in blood pressure lowering activity in anesthetized normotensive Sprague Dawley rats. The hypotensive effect was dose dependent which could be due to vasodilation mechanism and attributable to the high polyphenolic content of the plant. (7)
• Cardiovascular Effects: Study evaluated active fractions of L. ferrugineus and mechanisms of cardiovascular effects. Results suggest L. ferrugineus induced cardiovascular effects by stimulating muscarinic receptors, activating endothelium-derived nitric oxide-cGMP-relaxant pathway, promoting prostacyclin release and/or possibly through lengthening of NO half life. (8)
• Cardiovascular Effect / Vascular Relaxant and Hypotensive Effect: Study showed an n-butanol fraction of a methanol extract of L. ferrugineus was the most potent fraction in producing a concentration-dependent relaxation in vascular smooth muscle in vitro and a dose dependent blood pressure lowering effect in vivo. The effects are most likely attributable to its terpenoid content. (10)